公开(公告)号：US20210363566A1

公开(公告)日：2021-11-25

申请号：US16958683

申请日：2018-12-31

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  BIONANO HEALTH GUARD RESEARCH CENTER

Inventor： Hyun Gyu PARK ,  Hyo Yong KIM ,  Yong JU ,  Jun Ki AHN

IPC: C12Q1/683

Abstract: The present invention relates to a detection method for detecting a target RNA contained in a sample with high sensitivity by using nicking/extension chain reaction system-based isothermal nucleic acid amplification (NESBA) that uses activity of a cleavage enzyme and a DNA polymerase. The NESBA of the present invention is a new concept isothermal target RNA detection method that realizes higher amplification efficiency than the existing NASBA technology and is deemed to be utilizable as a new concept diagnosis technology that can replace conventional target RNA detection technologies.

公开(公告)号：US20230002804A1

公开(公告)日：2023-01-05

申请号：US17929834

申请日：2022-09-06

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  BIONANO HEALTH GUARD RESEARCH CENTER

Inventor： Hyun Gyu PARK ,  Hyo Yong KIM ,  Yong JU ,  Jun Ki AHN

IPC: C12Q1/683

Abstract: The present invention relates to a detection method for detecting a target RNA contained in a sample with high sensitivity by using nicking/extension chain reaction system-based isothermal nucleic acid amplification (NESBA) that uses activity of a cleavage enzyme and a DNA polymerase. The NESBA of the present invention is a new concept isothermal target RNA detection method that realizes higher amplification efficiency than the existing NASBA technology and is deemed to be utilizable as a new concept diagnosis technology that can replace conventional target RNA detection technologies.

公开(公告)号：US20200063183A1

公开(公告)日：2020-02-27

申请号：US16495435

申请日：2017-05-29

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Gyu PARK ,  Jun Ki AHN ,  Hyo Yong KIM ,  Yong JU

IPC: C12Q1/54

Abstract: The present invention relates to a method for detecting or quantifying ATP in a sample by using a blood glucose meter, the method including adding a sample to be detected to an ATP detection composition containing glucose and an enzyme involved in ATP regeneration so as to convert glucose into glucose-6-phosphate, and then measuring the glucose concentration by using a glucose meter, thereby detecting or quantifying ATP.