公开(公告)号：US20130302244A1

公开(公告)日：2013-11-14

申请号：US13765072

申请日：2013-02-12

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Kang Hyuk Choi ,  Kwang Jae Son ,  Jin-Hee Lee ,  Sung-Soo Nam ,  Sun Ju Choi

IPC: A61K51/00

CPC classification number: A61K51/00 ,  A61K51/02 ,  A61K51/1282

Abstract: The present invention provides a technique for adsorbing I-125 on a support for treating cancer and a method of preparing an I-125 seed using the same. Since a method of preparing iodine according to the present invention uses an intermediate having phosphate-based, oxalate-based, or arsenate-based anions introduced thereinto, the intermediate has a substitution effect of iodine 3 to 5 times higher than that of a typically used intermediate having chlorine anions introduced thereinto. According to the substitution effect, control of a radiation dose may be possible during the manufacturing of an iodine seed and an iodine seed may be prepared within a shorter period of time. Also, since an amount of residual radioactive iodine may be decreased as a result of a large amount of adsorption, an amount of radioactive iodine (I-125) waste may be decreased, and the effect thereof may be also high environmentally.

Abstract translation: 本发明提供了用于将I-125吸附在用于治疗癌症的支持体上的技术，以及使用该技术制备I-125种子的方法。 由于根据本发明的制备碘的方法使用引入其中含有基于磷酸盐，草酸盐或砷酸盐的阴离子的中间体，所以中间体具有碘的替代效应，比通常使用的碘的比例高3至5倍 带有氯阴离子的中间体。 根据替代效果，在制造碘种子期间可以控制辐射剂量，并且可以在更短的时间内制备碘种子。 另外，由于吸附量大，残留的放射性碘量可能会降低，因此放射性碘（I-125）废物的量可能会降低，其效果也可能较高。