公开(公告)号：US20140134109A1

公开(公告)日：2014-05-15

申请号：US13802322

申请日：2013-03-13

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Yong Dae PARK ,  Jeong Hoon PARK ,  Yong Jin YOON ,  Seung Tae YANG ,  Min Goo HUR

IPC: A61K49/00 ,  G01N21/64

CPC classification number: A61K49/006 ,  C07D237/14

Abstract: The present invention relates to a composition for detecting beta amyloid aggregates and a composition for diagnosing beta amyloid aggregation disease, comprising a 2-styrilpyridizine-3(2H)-one derivative or its pharmaceutically acceptable salt, to a diagnostic kit for diagnosing beta amyloid aggregation disease comprising said composition and to a method for detecting beta amyloid aggregates using said compositions to provide information for beta amyloid aggregation disease diagnosis.

Abstract translation: 本发明涉及一种用于检测β淀粉样蛋白聚集体的组合物和用于诊断β淀粉样蛋白聚集疾病的组合物，其包含2-苯乙烯吡啶啶-3（2H）酮衍生物或其药学上可接受的盐，用于诊断β淀粉样蛋白聚集的诊断试剂盒 包括所述组合物的疾病和使用所述组合物检测β淀粉样蛋白聚集体以提供β淀粉样蛋白聚集疾病诊断信息的方法。

公开(公告)号：US20220155310A1

公开(公告)日：2022-05-19

申请号：US17520972

申请日：2021-11-08

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Yong Dae PARK ,  Jong Ho Jeon ,  Min Ho Joe ,  Dong Eun Lee

IPC: G01N33/58 ,  G01N33/68 ,  C07D209/60 ,  C07D409/06 ,  C07D409/14

Abstract: The present invention relates to a water-soluble compound for the detection of beta-amyloid, and a production method thereof. The compound according to the present invention has excellent water-soluble properties, and thus can provide a water-soluble formulation for the detection of beta-amyloid. Accordingly, there is an effect that the compound can be useful as a composition for the detection of beta-amyloid through retinal imaging.