公开(公告)号：US10946037B1

公开(公告)日：2021-03-16

申请号：US16927193

申请日：2020-07-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Heh-In Im ,  Byung Sun Kim

IPC: A61K48/00 ,  C07H21/04 ,  A61K31/7105 ,  A61P25/34 ,  C12N15/113 ,  C12N15/86 ,  A61K9/00

Abstract: Disclosed is a pharmaceutical composition for preventing or treating nicotine addiction or withdrawal symptoms. The pharmaceutical composition includes miR-137 as an active ingredient. Overexpression of miR-137 in an animal model having nicotine addiction or withdrawal symptoms results in relief, prevention or amelioration of the symptoms. Therefore, the use of miR-137 contributes to the prevention or treatment of nicotine addiction or withdrawal symptoms and is expected to be useful for developing relevant therapeutic agents.

公开(公告)号：US10751360B1

公开(公告)日：2020-08-25

申请号：US16842310

申请日：2020-04-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Heh-In Im ,  Byung Sun Kim

IPC: A61K48/00 ,  C07H21/04 ,  A61K31/7105 ,  C12N15/86 ,  A61P25/34 ,  C12N15/113 ,  A61K9/00

Abstract: Disclosed is a pharmaceutical composition for preventing or treating nicotine addiction or withdrawal symptoms. The pharmaceutical composition includes miR-137 as an active ingredient. Overexpression of miR-137 in an animal model having nicotine addiction or withdrawal symptoms results in relief, prevention or amelioration of the symptoms. Therefore, the use of miR-137 contributes to the prevention or treatment of nicotine addiction or withdrawal symptoms and is expected to be useful for developing relevant therapeutic agents.