公开(公告)号：US20160121293A1

公开(公告)日：2016-05-05

申请号：US14927942

申请日：2015-10-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Murale DHIRAJ ,  Seong Cheol HONG ,  Ji Hyeon YUN ,  Chang No YOON ,  Jun Seok LEE

IPC: B01J19/12 ,  C07K14/765 ,  C07D235/14 ,  C07D263/57 ,  C07D277/66 ,  C07D235/12

CPC classification number: C07K14/765 ,  C07D235/12 ,  C07D235/14 ,  C07D263/57 ,  C07D277/66

Abstract: Provided are a labelling agent including a compound of the following Formula 1, a labelling composition, a method of labelling a protein with the labelling agent, and a method of detecting the protein using the labelling agent: wherein R1, R2, R3, R4, R5, R6, and R8 are independently H, substituted or unsubstituted —C1-10-alkyl-, —C2-10-alkenyl, or —C2-10-alkynyl, R7 is H or —NR9R10, R9 and R10 are independently H, substituted or unsubstituted —C1-10-alkyl-, —C2-10-alkenyl, or —C2-10-alkynyl, X is —NR11, —O, or S, R11 is H, substituted or unsubstituted —C1-10-alkyl-, —C2-10-alkenyl, or —C2-10-alkynyl, Y is —OR12 or —NR13R14, R12 is H, substituted or unsubstituted —C1-10-alkyl-, —C2-10-alkenyl, or —C2-10-alkynyl, and R13 and R14 are independently H, substituted or unsubstituted —C1-10-alkyl-, —C2-10-alkenyl, or —C2-10-alkynyl.

Abstract translation: 本发明提供包含下列化学式1的化合物，标记组合物，用标记试剂标记蛋白质的方法的标记试剂和使用该标记试剂检测蛋白质的方法：其中R1，R2，R3，R4， R 5，R 6和R 8独立地是H，取代或未取代的C 1-10 - 烷基 - ， - C 2-10 - 烯基或-C 2-10 - 炔基，R 7是H或-NR 9 R 10，R 9和R 10独立地是H， 取代或未取代的C 1-10 - 烷基 - ， - C 2-10 - 烯基或-C 2-10 - 炔基，X是-NR 11，-O或S，R 11是H，取代或未取代的C 1-10烷基 - ， - C2-10 - 烯基或-C2-10-炔基，Y是-OR12或-NR13R14，R12是H，取代或未取代的-C1-10-烷基 - ， - C2-10 - 烯基或-C2 -10-炔基，R 13和R 14独立地为H，取代或未取代的C 1-10 - 烷基 - ， - C 2-6 - 烯基或-C 2-10炔基。

公开(公告)号：US20190274554A1

公开(公告)日：2019-09-12

申请号：US16463136

申请日：2017-11-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chang No YOON ,  Hong Seog SEO ,  Won Seok HAN ,  Jin Kak LEE ,  Jun Seok LEE

IPC: A61B5/026 ,  A61B5/021 ,  A61B5/024 ,  G16H50/30

Abstract: Provided is a method of determining circulatory disease potential. The method includes: a user data receiving operation of receiving user data about a blood pressure and a blood flow of a user; a pattern calculating operation of calculating a three-dimensional (3D) user pattern for the user based on the received user data; a pattern comparing operation of comparing a comparison target pattern calculated based on data about blood pressures and blood flows of a normal person and a circulatory patient stored in a database, with the calculated user pattern; and a result output operation of outputting, based on a result of the comparison, circulatory disease potential visualizing to which of the normal person and the circulatory patient stored in the database the user is closer.