公开(公告)号：US20190328721A1

公开(公告)日：2019-10-31

申请号：US16394223

申请日：2019-04-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： GiHoon NAM ,  Yoo Soo Yang ,  In-San Kim ,  Seung-Yoon Park

IPC: A61K31/4409 ,  A61P35/00 ,  A61P37/04 ,  A61K39/395

Abstract: Described are methods for activating dendritic cells using a Rho-related protein kinase (ROCK) inhibitor, optionally in combination with one or more of an immunogenic cell death-inducing chemotherapeutic, photodynamic therapy, or radiation therapy. The methods and treated cells are useful, for example, in treating cancer, optionally in combination with one or more of an immunogenic cell death-inducing chemotherapeutic, immune checkpoint inhibitor, photodynamic therapy, or radiation therapy.