公开(公告)号：US12122999B2

公开(公告)日：2024-10-22

申请号：US17745416

申请日：2022-05-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Heh-In Im ,  Sangjoon Lee ,  Ji Eun Choi

IPC: C12N15/113 ,  A61P25/28

CPC classification number: C12N15/113 ,  A61P25/28 ,  C12N2310/14 ,  C12N2310/531

Abstract: Disclosed is a composition for preventing or treating a degenerative brain disease. The composition includes, as an active ingredient, a MECP2 inhibitor for treating the degenerative brain disease, a polynucleotide encoding the MECP2 inhibitor or a recombinant virus containing the MECP2 inhibitor. The composition is useful for the treatment of a degenerative brain disease (particularly Alzheimer's syndrome) caused by beta-amyloid. In addition, the composition is effective in improving or ameliorating deterioration of cognitive functions and social deficits caused by Alzheimer's syndrome.