公开(公告)号：US20140155635A1

公开(公告)日：2014-06-05

申请号：US14066053

申请日：2013-10-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong Yoon ,  Ji Nyeo Kim

IPC: C07D313/00 ,  C07D493/08 ,  C07D317/30 ,  C07D407/10 ,  C07D319/08 ,  C07D317/32

CPC classification number: C07D313/00 ,  C07D317/20 ,  C07D317/22 ,  C07D317/30 ,  C07D317/32 ,  C07D319/08 ,  C07D407/10 ,  C07D493/08

Abstract: Disclosed are a novel resorcyclic acid lactone compound with inhibitory activity against protein kinases, a pharmaceutically acceptable salt thereof, a method for the synthesis thereof, and a pharmaceutical composition for the treatment and prevention of various cancer diseases comprising the same as an active ingredient. The novel resorcyclic acid lactone compound is useful as a therapeutic for cancer diseases, especially blood cancer, inter alia, acute myeloid leukemia (AML).

Abstract translation: 本发明公开了一种对蛋白激酶具有抑制活性的新型重链内酯化合物，其药学上可接受的盐，其合成方法以及用于治疗和预防包含其的活性成分的各种癌症疾病的药物组合物。 新型的再环内酯化合物可用作癌症疾病，特别是血液癌，尤其是急性骨髓性白血病（AML）的治疗剂。