公开(公告)号：US10190120B2

公开(公告)日：2019-01-29

申请号：US15671901

申请日：2017-08-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gyo Chang Keum ,  Eun Kyoung Bang ,  Jin Bum Kim

IPC: C07F3/06 ,  C07D401/12 ,  A61K48/00 ,  C12N15/113 ,  C07D213/38 ,  C07D495/04 ,  C12N15/11

Abstract: Provided herein are a novel Zn-DPA complex compound and an siRNA delivery system including the same as a transporter, the Zn-DPA complex compound including: a phosphate-directing functional part of zinc (II)-dipicolylamine (“Zn-DPA”); a cell membrane-directing functional part; and a linker part that links the phosphate-directing functional part and the cell membrane-directing functional part. The Zn-DPA complex compound has low toxicity and efficiently delivers siRNA to cells, thereby useful in various ways for various studies and diagnosis and treatment of diseases, which use siRNA.