公开(公告)号：US11920118B2

公开(公告)日：2024-03-05

申请号：US17081723

申请日：2020-10-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Mee Jung ,  Soo Hyun Kim ,  Justin Jihong Chung ,  Jin Yoo ,  Tae Hee Kim

IPC: C12M1/00

CPC classification number: C12M29/04 ,  C12M23/26

Abstract: Provided are a method for fabricating a highly elastic porous polymer membrane, a method for manufacturing a cell culture system using a porous polymer membrane fabricated by the fabrication method, and a cell culture system manufactured by the manufacturing method. The porous polymer membrane can be fabricated by spin coating a mixture solution containing a biodegradable elastomeric polymer and a water-soluble moisture absorbent in an optimum ratio while maintaining a high relative humidity. The porous polymer membrane has a uniform thickness and a uniform pore size and is highly elastic. In addition, the thickness and pore size of the porous polymer membrane can be controlled. The porous polymer membrane can induce active cell-cell interaction during cell co-culture due to its high porosity. The porous polymer membrane enables control over cell alignment or array due to its high biocompatibility and elasticity. The porous polymer membrane can be utilized in a platform for inducing stem cell differentiation, a lab-on-a-chip, a synthetic skin simulant platform, etc.