公开(公告)号：US20240358853A1

公开(公告)日：2024-10-31

申请号：US18598746

申请日：2024-03-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Heh-In IM ,  Jin Hee BAE ,  Nazarii FRANKIV

IPC: A61K48/00 ,  A61K9/00 ,  A61K38/17 ,  A61P25/24 ,  C12N15/86 ,  G01N33/68

CPC classification number: A61K48/005 ,  A61K9/0019 ,  A61K38/1709 ,  A61P25/24 ,  C12N15/86 ,  G01N33/6854 ,  G01N33/6893 ,  C12N2750/14143

Abstract: According to the present disclosure, the relation between the MeCP2 expression level and depression in D2R neurons of the ventral striatum was first found, and it was confirmed that MeCP2 in D2R neurons of the ventral striatum was significantly decreased due to depressive symptoms, and depressive symptoms were improved when MeCP2 expression in the neurons was up-regulated. Accordingly, the expression level of MeCP2 in D2R neurons of the ventral striatum is provided as a biomarker for diagnosing depression and the up-regulation of the MeCP2 expression is provided as a treatment strategy for depression, and thus, it is expected to be useful as a development platform for drugs for preventing or treating depression in the future.