公开(公告)号：US12006498B2

公开(公告)日：2024-06-11

申请号：US16761151

申请日：2018-10-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Sang Hoon Jung ,  Young-Joo Kim ,  Dae-geun Song ,  Young Nyun Park ,  Jeong Eun Yoo ,  Hyung Jin Rhee ,  Youngsic Jeon

IPC: C12N15/113 ,  A61P1/16 ,  A61P35/00

CPC classification number: C12N15/113 ,  A61P1/16 ,  A61P35/00 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/127 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/3181 ,  C12N2310/531

Abstract: In the present specification, on the basis of the correlation between prospero homeobox protein 1 (PROX1) and telomerase reverse transcriptase (TERT), a composition for regulating expression of TERT, a method for screening a TERT expression regulator, a composition for diagnosing a TERT expression status, a diagnostic kit, a method for providing information for diagnosis, or a method for providing information for cancer diagnosis are disclosed. Specifically, in one aspect, the PROX1 of the present disclosure may bind to a TERT promoter, in particular a mutant TERT promoter in which base substitution occurs at the −124 or −146 bp position to regulate the expression of TERT, and the expression of TERT in non-hepatitis B virus-associated liver cancer can be inhibited specifically among liver cancers.

公开(公告)号：US09682113B2

公开(公告)日：2017-06-20

申请号：US15132899

申请日：2016-04-19

Applicant: Korea Institute of Science and Technology

Inventor： Sang Hoon Jung ,  Kyung A Kim ,  Suk-Woo Kang ,  Joo Young Lee ,  Hong Ryul Ahn ,  Youngwoo Song

IPC: A61K36/44 ,  A61K9/00 ,  A23L1/30 ,  A23L33/105

CPC classification number: A61K36/44 ,  A23L33/105 ,  A61K9/0053

Abstract: Disclosed is a method for preventing, improving and/or treating cornea damage or a corneal disease, including administering an effective amount of an extract of a persimmon tree for preventing, improving or treating cornea damage to a subject in need thereof. The extract may be a persimmon leaf extract and the extract is effective in suppressing inflammation of the cornea and protecting corneal cells.

公开(公告)号：US10697945B2

公开(公告)日：2020-06-30

申请号：US15685510

申请日：2017-08-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yongsoo Choi ,  Jeongsook Shin ,  Cheol-Ho Pan ,  Sang Min Kim ,  Jung-Seok Yang ,  Kyungsu Kang ,  Sang Hoon Jung

IPC: G01N30/72 ,  G01N30/06 ,  G01N30/02 ,  G01N30/88

Abstract: Provided is an amine group-derivatized composition including a Boc compound for liquid chromatography-mass spectrometry (LC-MS) analysis, and when the amine group-derivatized composition is used in analysis using reverse-phase LC-MS, it is possible to effectively analyze compounds including an amine group and an amino acid at a low cost in a short time.