公开(公告)号：US20220411420A1

公开(公告)日：2022-12-29

申请号：US17706628

申请日：2022-03-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Seo Jung HAN ,  Sang Hee LEE ,  Hee Jin JEONG ,  Hye Lim LEE ,  Chan Sun PARK ,  Sung Joon KIM

IPC: C07D471/04 ,  C07D487/04

Abstract: Disclosed is a novel pyrrolopyrimidine derivative compound, a tautomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, associated with a compound for inhibiting ENPP1, a composition for inhibiting ENPP1, and a method of inhibiting ENPP1.

公开(公告)号：US20210061810A1

公开(公告)日：2021-03-04

申请号：US17002748

申请日：2020-08-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Seo Jung HAN ,  Tae Bo SIM ,  Do Hee OH ,  Jae Eun CHEONG ,  Dong Keon HWANG

IPC: C07D487/04 ,  A61P35/00

Abstract: Disclosed are a compound selected from novel pyrimido[4,5-d]pyrimidin-2-one derivative compounds having excellent anti-proliferative activity against cancer cells, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the compound as an active ingredient, and an anticancer composition against cancer cells, containing the compound as an active ingredient. The compounds of this invention exhibit most excellent selective inhibitory activity agaist LCK and anti-proliferative activity against cancer cells, thus being useful for inhibiting cancer cells, and for preventing or treating cancer metastasis and proliferative diseases.