公开(公告)号：US20210115509A1

公开(公告)日：2021-04-22

申请号：US16703619

申请日：2019-12-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Chun RYU ,  YOON CHO

IPC: C12Q1/6874 ,  C12N15/10

Abstract: Disclosed are a biomarker for identifying specific exposure to ketones, which are one of environmentally harmful substances that may be exposed in the indoor atmosphere environment, and a method for identifying exposure to ketones using the same. More specifically, disclosed are a biomarker composition and a kit for identifying specific exposure to ketones containing genes, the expression of which is increased or decreased specifically in human bronchial epithelial cell lines by exposure to five kinds of ketones including acetone, butanone, pentanone, hexanone and heptanone, and a method for identifying exposure to ketones using the same. Fast-throughput sequencing using a biomarker including a gene showing a changed expression pattern upon exposure to five types of ketones including acetone, butanone, pentanone, hexanone and heptanone is useful for rapidly and accurately monitoring and determining the contamination level of ketones in the environment.