公开(公告)号：US20190284143A1

公开(公告)日：2019-09-19

申请号：US16347480

申请日：2017-11-01

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kwangho LEE ,  Gildon CHOI ,  Na Ri LEE ,  Sang Jun PARK ,  Myoung Eun JUNG ,  Seong Jin KIM ,  Kyung-Min YANG ,  Jihee LEE

IPC: C07D239/48 ,  C07D405/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K9/00

Abstract: The present invention relates to novel pyrimidine compounds, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer and inflammatory disease. The novel pyrimidine compounds according to the present invention remarkably inhibits activity of DRAK that inhibits signal systems of TGF-β, which is known to suppress cancer growth, and thus the novel pyrimidine compounds can be used as a pharmaceutical composition for preventing or treating cancer and can be used as a pharmaceutical composition for preventing or treating inflammatory disease.