公开(公告)号：US20250145625A1

公开(公告)日：2025-05-08

申请号：US18725482

申请日：2022-12-30

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  UIF (UNIVERSITY INDUSTRY FOUNDATION), YONSEI UNIVERSITY

Inventor： Joon JEONG ,  Hye Kyoung SHIN ,  Sun Joo AHN ,  Hee Jong LIM ,  Jin Sook SONG ,  Seong Hwan KIM ,  Chong Hak CHAE ,  Eun Hye KIM ,  Ji Hye CHOI ,  Jong Seung LIM ,  Eun Soo JANG ,  Jin Woo SONG ,  Do Hyun KIM

IPC: C07D487/04 ,  A61K31/337 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of tumors, containing a novel pyrazolopyrimidine compound or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered in combination with other anticancer agents, and thus can be effectively used as a composition for preventing or treating cancer.

公开(公告)号：US20170145007A1

公开(公告)日：2017-05-25

申请号：US15319151

申请日：2015-05-21

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Chang Soo YUN ,  Hyoung Rae KIM ,  Sung Yun CHO ,  Hee Jung JUNG ,  Kwangho LEE ,  Chong Hak CHAE ,  Chong Ock LEE ,  Chi Hoon PARK ,  Pilho KIM ,  Jong Yeon HWANG ,  Jae DU HA ,  Sun Joo AHN

IPC: C07D471/04 ,  C07D405/14 ,  C07D401/14 ,  C07D403/12 ,  C07D401/12

CPC classification number: C07D471/04 ,  A61K31/506 ,  C07D209/04 ,  C07D239/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14

Abstract: The present invention relates to a pyrimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for prevention or treatment of cancer comprising the same as an effective ingredient. A compound according to the present invention has the good effect of inhibiting anaplastic lymphoma kinase (ALK) activity, whereby a therapeutic effect on cancer cells having an anaplastic lymphoma kinase (ALK) fusion protein such as EML4-ALK, NPM-ALK, etc. can be enhanced and it is expected that a recurrence of cancer will be effectively inhibited. As such, the compound can be effectively used in a pharmaceutical composition for prevention or treatment of cancer.