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公开(公告)号：US10426783B2
公开(公告)日：2019-10-01
申请号：US15387113
申请日：2016-12-21
Inventor： Tatsuro Ishibashi , Shintaro Nakao , Ryoichi Arita , Ken Mizuno , Akifumi Tsuchiura
IPC: A61K31/551 , A61K9/00 , A61K31/496 , C07D401/12 , A61K47/10
Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(−)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
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公开(公告)号：US10034885B2
公开(公告)日：2018-07-31
申请号：US15511736
申请日：2015-09-24
Applicant: KOWA COMPANY, LTD.
Inventor： Hiroyuki Takahashi , Kiyoshi Toya , Akifumi Tsuchiura
IPC: A61K31/551 , C07D401/12 , A61K9/00
CPC classification number: A61K31/551 , A61K9/0048 , A61K31/496 , A61P27/02
Abstract: The present invention provides a novel corneal thickness modulating agent. The present invention pertains to a corneal thickness modulating agent containing 1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof or a solvate thereof.
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Patent Agency Ranking
公开(公告)号：US20170100409A1
公开(公告)日：2017-04-13
申请号：US15387113
申请日：2016-12-21
Inventor： Tatsuro Ishibashi , Shintaro Nakao , Ryoichi Arita , Ken Mizuno , Akifumi Tsuchiura
IPC: A61K31/551 , A61K9/00
CPC classification number: A61K31/551 , A61K9/0046 , A61K9/0048 , A61K31/496 , A61K47/10 , C07D401/12
Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(−)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
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公开(公告)号：US20240216390A1
公开(公告)日：2024-07-04
申请号：US18605928
申请日：2024-03-15
Inventor： Tatsuro Ishibashi , Shintaro Nakao , Ryoichi Arita , Ken Mizuno , Akifumi Tsuchiura
IPC: A61K31/551 , A61K9/00 , A61K31/496 , C07D401/12 , A61K47/10
CPC classification number: A61K31/551 , A61K9/0046 , A61K9/0048 , A61K31/496 , C07D401/12 , A61K47/10
Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(-)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
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公开(公告)号：US20160339018A1
公开(公告)日：2016-11-24
申请号：US14362850
申请日：2014-03-03
Inventor： Tatsuro Ishibashi , Shintaro Nakao , Ryoichi Arita , Ken Mizuno , Akifumi Tsuchiura
IPC: A61K31/496 , A61K9/00
CPC classification number: A61K31/551 , A61K9/0046 , A61K9/0048 , A61K31/496 , A61K47/10 , C07D401/12
Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(−)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
Abstract translation: 本文公开了眼底疾病，特别是糖尿病性视网膜病变或年龄相关性黄斑变性的预防或治疗剂。 眼底疾病的预防或治疗剂包括：（S） - （ - ） - 1-（4-氟-5-异喹啉磺酰基）-2-甲基-1,4-高哌嗪，其盐或其溶剂合物， 作为活性成分。
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公开(公告)号：US20170290840A1
公开(公告)日：2017-10-12
申请号：US15511736
申请日：2015-09-24
Applicant: KOWA COMPANY, LTD.
Inventor： Hiroyuki Takahashi , Kiyoshi Toya , Akifumi Tsuchiura
IPC: A61K31/551 , A61K9/00
CPC classification number: A61K31/551 , A61K9/0048 , A61K31/496 , A61P27/02
Abstract: The present invention provides a novel corneal thickness modulating agent. The present invention pertains to a corneal thickness modulating agent containing 1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof or a solvate thereof.
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公开(公告)号：US20140378441A1
公开(公告)日：2014-12-25
申请号：US14481467
申请日：2014-09-09
Inventor： Tatsuro Ishibashi , Shintaro Nakao , Ryoichi Arita , Ken Mizuno , Akifumi Tsuchiura
IPC: A61K31/551 , A61K9/00
CPC classification number: A61K31/551 , A61K9/0046 , A61K9/0048 , A61K31/496 , A61K47/10 , C07D401/12
Abstract: Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The prophylactic or therapeutic agent for ocular fundus disease comprising: (S)-(−)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine, a salt thereof, or a solvate thereof, as an active ingredient.
Abstract translation: 本文公开了眼底疾病，特别是糖尿病性视网膜病变或年龄相关性黄斑变性的预防或治疗剂。 眼底疾病的预防或治疗剂包括：（S） - （ - ） - 1-（4-氟-5-异喹啉磺酰基）-2-甲基-1,4-高哌嗪，其盐或其溶剂合物， 作为活性成分。
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