公开(公告)号：US20170304273A1

公开(公告)日：2017-10-26

申请号：US15513277

申请日：2015-09-28

Applicant: KOWA COMPANY, LTD.

Inventor： Yuta Inokuchi ,  Haruki Shibata ,  Toshiaki Takizawa

IPC: A61K31/423 ,  A61K31/4152 ,  A61K45/06 ,  A61K45/00

CPC classification number: A61K31/423 ,  A61K31/4152 ,  A61K31/421 ,  A61K31/505 ,  A61K45/00 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention provides a combination-drug composition and a combination use of pharmaceuticals for preventing and/or treating dyslipidemic conditions such as hyper-LDL cholesterolemia in mammals, including humans.This invention pertains to a drug composition for preventing and/or treating dyslipidemia and the like, the drug composition including the following: (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy] butyric acid, a salt thereof, or a solvate of either; and (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl} acetic acid, a salt thereof, or a solvate of either.

公开(公告)号：US09968592B2

公开(公告)日：2018-05-15

申请号：US15513277

申请日：2015-09-28

Applicant: KOWA COMPANY, LTD.

Inventor： Yuta Inokuchi ,  Haruki Shibata ,  Toshiaki Takizawa

IPC: A61K31/423 ,  A61K31/4152 ,  A61K45/06 ,  A61K45/00

CPC classification number: A61K31/423 ,  A61K31/4152 ,  A61K31/421 ,  A61K31/505 ,  A61K45/00 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention provides a combination-drug composition and a combination use of pharmaceuticals for preventing and/or treating dyslipidemic conditions such as hyper-LDL cholesterolemia in mammals, including humans.This invention pertains to a drug composition for preventing and/or treating dyslipidemia and the like, the drug composition including the following: (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy] butyric acid, a salt thereof, or a solvate of either; and (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methyl sulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl} acetic acid, a salt thereof, or a solvate of either.

公开(公告)号：US20160136138A1

公开(公告)日：2016-05-19

申请号：US14903114

申请日：2014-07-09

Applicant: KOWA COMPANY, LTD.

Inventor： Haruki Shibata ,  Toshiaki Takizawa

IPC: A61K31/423

Abstract: The present invention provides a compound useful in the prevention and treatment of nonalcoholic fatty liver disease. The invention relates to a drug for the prevention and/or treatment of nonalcoholic fatty liver disease, the drug having as an active ingredient (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid, a salt thereof, or a solvate of these.

Abstract translation: 本发明提供了用于预防和治疗非酒精性脂肪性肝病的化合物。 本发明涉及一种用于预防和/或治疗非酒精性脂肪肝疾病的药物，该药物具有作为活性成分的（R）-2- [3 - [[N-（苯并恶唑-2-基）-N-3 - （4-甲氧基苯氧基）丙基]氨基甲基]苯氧基]丁酸，其盐或它们的溶剂合物。

公开(公告)号：US20140221390A1

公开(公告)日：2014-08-07

申请号：US14162181

申请日：2014-01-23

Applicant: Kowa Company, Ltd.

Inventor： Haruki Shibata ,  Yasunobu Yoshinaka ,  Kimiyuki Shibuya

IPC: C07D401/12

CPC classification number: C07D401/12 ,  A61K31/496

Abstract: Provided is a compound useful in the prevention and treatment of non-alcoholic steatohepatitis. A prophylactic and/or therapeutic agent for non-alcoholic steatohepatitis which contains, as the active ingredient, 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide, an acid-addition salt thereof, or a solvate of the same.

Abstract translation: 提供了用于预防和治疗非酒精性脂肪性肝炎的化合物。 含有作为活性成分的2- [4- [2-（苯并咪唑-2-基硫基）乙基]哌嗪-1-基] -N- [2,4（ⅰ））的非酒精性脂肪性肝炎的预防和/或治疗剂 - 双（甲硫基）-6-甲基-3-吡啶基]乙酰胺，其酸加成盐或其溶剂合物。