公开(公告)号：US11608320B2

公开(公告)日：2023-03-21

申请号：US17145357

申请日：2021-01-10

Applicant: KUWAIT UNIVERSITY

Inventor： Charles Ifeamalume Ezeamuzie ,  Oludotun Adebayo Phillips

IPC: C07D263/06 ,  A61P11/06 ,  A61P37/08 ,  A61K31/421

Abstract: Oxazolidinone hydroxamic acid derivatives of the general formula (I): where R1 is hydrogen or hexanoyl and R2 is amino, methyl, ethyl, propyl, isopropyl, cyclopropyl, butyl, isobutyl, cyclobutyl, pentyl, cyclopentyl, hexyl or heptyl, and pharmaceutically acceptable salts thereof, act as dual inhibitors of 5-lipoxygenase and mast cell degranulation. The oxazolidinone hydroxamic acid derivatives or pharmaceutically acceptable salts thereof can be used in the prevention and treatment of asthma and allergies, as well as inflammatory conditions.