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公开(公告)号：US20220380467A1
公开(公告)日：2022-12-01
申请号：US17727288
申请日：2022-04-22
申请人： Kymab Limited
发明人： Richard Charles Alfred SAINSON , Stephen John ARKINSTALL , Jamie Iain CAMPBELL , Mohammed Hanif ALI , E-Chiang LEE , Matthew John MCCOURT , Nikole SANDY , Cassandra VAN KRINKS , Volker GERMASCHEWSKI , Ian KIRBY , Miha KOSMAC , Thomas GALLAGHER , Cecilia DEANTONIO , Stephen Douglas GILLIES
IPC分类号： C07K16/28 , A61K47/68 , A61P35/00 , A61K31/282 , A61K39/395 , C07K14/55 , C07K16/46 , G01N33/50
摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.
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公开(公告)号：US20220403029A1
公开(公告)日：2022-12-22
申请号：US17727309
申请日：2022-04-22
申请人： Kymab Limited
发明人： Richard Charles Alfred SAINSON , Stephen John ARKINSTALL , Jamie Iain CAMPBELL , Mohammed Hanif ALI , E-Chiang LEE , Matthew John MCCOURT , Nikole SANDY , Cassandra VAN KRINKS , Volker GERMASCHEWSKI , Ian KIRBY , Miha KOSMAC , Thomas GALLAGHER , Cecilia DEANTONIO , Stephen Douglas GILLIES
IPC分类号： C07K16/28 , A61K47/68 , A61P35/00 , A61K31/282 , A61K39/395 , C07K14/55 , C07K16/46 , G01N33/50
摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.
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公开(公告)号：US20220396623A1
公开(公告)日：2022-12-15
申请号：US17747886
申请日：2022-05-18
申请人： KYMAB LIMITED
摘要： Therapeutic use and dosing regimen of anti-ICOS antibodies or antigen-binding fragments thereof for modulating the ratio between regulatory T cells and effector T cells, stimulating the immune system of patients, and/or treating tumours or cancers, as monotherapy or combination therapy, e.g., with anti-PD-L1 antibodies or antigen-binding fragments thereof.
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公开(公告)号：US20200317786A1
公开(公告)日：2020-10-08
申请号：US16955197
申请日：2018-12-19
申请人： KYMAB LIMITED
发明人： Aksana LABOKHA , Nahida PARVEEN , Jacob GALSON , Richard Charles Alfred SAINSON , Stephen John ARKINSTALL
摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Combinations of anti-ICOS antibodies and other drugs for immunooncology.
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公开(公告)号：US20190330345A1
公开(公告)日：2019-10-31
申请号：US16323980
申请日：2017-08-09
申请人： Kymab Limited
发明人： Richard Charles Alfred SAINSON , Stephen John ARKINSTALL , Jamie Iain CAMPBELL , Mohammed Hanif ALI , E-Chiang LEE , Matthew John MCCOURT , Nikole SANDY , Cassandra VAN KRINKS , Volker GERMASCHEWSKI , Ian KIRBY , Miha KOSMAC , Thomas GALLAGHER , Cecilia DEANTONIO , Stephen Douglas GILLIES
IPC分类号： C07K16/28 , C07K16/46 , A61K47/68 , A61P35/00 , C07K14/55 , A61K31/282 , A61K39/395 , G01N33/50
摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.
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公开(公告)号：US20190202917A1
公开(公告)日：2019-07-04
申请号：US16311421
申请日：2017-06-20
申请人： KYMAB LIMITED
发明人： Jamie CAMPBELL , Nikole SANDY , Cassandra VAN KRINKS , Stephen John ARKINSTALL , Volker GERMASCHEWSKI , Ian KIRBY , Miha KOSMAC , Thomas GALLAGHER , Cecilia DEANTONIO , Stephen Douglas GILLIES , Matthew John MCCOURT , Richard Charles Alfred SAINSON , Mohammed Hanif ALI , E-Chiang LEE
CPC分类号： C07K16/2827 , A61K2039/505 , C07K14/55 , C07K16/28 , C07K16/2803 , C07K16/468 , C07K19/00 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/74
摘要： Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.
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公开(公告)号：US20180066058A1
公开(公告)日：2018-03-08
申请号：US15698600
申请日：2017-09-07
申请人： KYMAB LIMITED
发明人： Richard Charles Alfred SAINSON , Stephen John ARKINSTALL , Jamie Iain CAMPBELL , Mohammed Hanif ALI , E-Chiang LEE , Matthew John MCCOURT , Nikole SANDY , Cassandra VAN KRINKS , Volker GERMASCHEWSKI , Ian KIRBY , Miha KOSMAC , Thomas GALLAGHER , Cecilia DEANTONIO , Stephen D. GILLIES
CPC分类号： C07K16/2827 , A61K2039/505 , C07K14/55 , C07K16/28 , C07K16/2803 , C07K16/468 , C07K19/00 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/74
摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.
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