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公开(公告)号：US20180169088A1
公开(公告)日：2018-06-21
申请号：US15578758
申请日：2016-06-02
发明人： Takahiro GOTO , Hitoshi KOZUKA , Mizuho SHIBATA , Wataru MINAGAWA , Norihiro KANAYAMA , Chifuyu TORIUMI
IPC分类号： A61K31/4709 , A61K9/08
CPC分类号： A61K31/4709 , A61K9/08 , A61P31/04
摘要： An aqueous drug that contains the compound represented by formula (1) or a salt thereof and in which the precipitation and the chemical dissolution of the compound of formula (1) or of a salt thereof is inhibited. An aqueous drug containing: the compound represented by formula (1) or a salt thereof; and a magnesium compound. The aqueous drug has a pH of 5.8-6.9. The concentration of the compound represented by formula (1) is 3 mg/mL or more.
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公开(公告)号：US20180147199A1
公开(公告)日：2018-05-31
申请号：US15578764
申请日：2016-06-02
发明人： Wataru MINAGAWA , Hitoshi KOZUKA , Mizuho SHIBATA , Takahiro GOTO , Chifuyu TORIUMI , Norihiro KANAYAMA
IPC分类号： A61K31/4709 , A61K47/02 , A61P31/04 , A61K9/08
CPC分类号： A61K31/4709 , A61K9/08 , A61K47/02 , A61P31/04
摘要： A novel technique with which it is possible to suppress chemical degradation of a compound represented by general formula (1) or a salt thereof in an aqueous liquid formulation containing a compound represented by general formula (1) or a salt thereof. A method for suppressing the generation of a compound represented by general formula (2) or a salt thereof including containing a compound represented by general formula (1) or a salt thereof and a magnesium compound in an aqueous liquid formulation.
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