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![QUINAZOLINONE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF](/abs-image/US/2012/04/19/US20120095214A1/abs.jpg.150x150.jpg)
1.发明申请QUINAZOLINONE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF 有权喹唑啉酮连接的吡咯并[2,1-C] [1,4]苯并咪唑杂化物作为潜在的抗原药剂及其制备方法公开(公告)号：US20120095214A1
公开(公告)日：2012-04-19
申请号：US13129995
申请日：2009-07-13
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides a compound of general formulae 5a-r, 9a-i to 13a-i and 17a-i to 22a-i, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formulae 5a-r, 9a-i to 13a-i and 17a-i to 22a-i.
摘要翻译： 本发明提供了可用作抗人肿瘤细胞系的潜在抗肿瘤剂的通式5a-r，9a-i至13a-i和17a-i至22a-i的化合物。 本发明还提供制备通式5a-r，9a-i至13a-i和17a-i至22a-i的吡咯并[2,1-c] [1,4]苯并二氮杂杂化物的方法。
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![Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof](/abs-image/US/2014/04/08/US08691811B2/abs.jpg.150x150.jpg)
2.发明授权Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof 有权喹唑啉酮联吡咯并[2,1-c] [1,4]苯并二氮杂杂交体作为潜在的抗癌剂及其制备方法公开(公告)号：US08691811B2
公开(公告)日：2014-04-08
申请号：US13129995
申请日：2009-07-13
IPC分类号： C07D487/04 , A61K31/5517
CPC分类号： C07D487/04
摘要： The present invention provides a compound of general formulae 5a-r, 9a-i to 13a-i and 17a-i to 22a-i, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formulae 5a-r, 9a-i to 13a-i and 17a-i to 22a-i.
摘要翻译： 本发明提供了可用作抗人肿瘤细胞系的潜在抗肿瘤剂的通式5a-r，9a-i至13a-i和17a-i至22a-i的化合物。 本发明还提供制备通式5a-r，9a-i至13a-i和17a-i至22a-i的吡咯并[2,1-c] [1,4]苯并二氮杂杂化物的方法。
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3.发明授权Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids as potential anticancer agents and process for the preparation thereof 有权异恶唑/异恶唑啉/考布他汀联合二氢喹唑啉酮杂合物作为潜在的抗癌剂及其制备方法公开(公告)号：US08883809B2
公开(公告)日：2014-11-11
申请号：US13129974
申请日：2009-09-08
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D239/91 , C07D413/12
摘要： The present invention provides a compound of general formulae 3a-i to 6a-i, 7a-i to 10a-i, 12a-i to 15a-i, 16a-i to 19a-i, 21a-i to 24a-i, 25a-i to 28a-i, 30a-i to 33a-i, 34a-i to 37a-i and 39a-i to 42a-i, 43a-i to 46a-i useful as potential antitumour agents against human cancer cell lines and a process for the preparation thereof.
摘要翻译： 本发明提供通式3a-i至6a-i，7a-i至10a-i，12a-i至15a-i，16a-i至19a-i，21a-i至24a-i，25a -i至28a-i，30a-i至33a-i，34a-i至37a-i和39a-i至42a-i，43a-i至46a-i可用作抗人肿瘤细胞系的潜在抗肿瘤剂 其制备方法。
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4.发明申请ISOXAZOLE/ISOXAZOLINE/COMBRETASTATIN LINKED DIHYDROQUINAZOLINONE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF 有权ISOXAZOLE / ISOXAZOLINE / COMBRETASTATIN连接的二氢喹诺酮混合物作为潜在的反应剂代理及其制备方法公开(公告)号：US20120283439A1
公开(公告)日：2012-11-08
申请号：US13129974
申请日：2009-09-08
IPC分类号： C07D413/04 , C07D239/91
CPC分类号： C07D239/91 , C07D413/12
摘要： The present invention provides a compound of general formulae 3a-i to 6a-i, 7a-i to 10a-i, 12a-i to 15a-i, 16a-i to 19a-i, 21a-i to 24a-i, 25a-i to 28a-i, 30a-i to 33a-i, 34a-i to 37a-i and 39a-i to 42a-i, 43a-i to 46a-i useful as potential antitumour agents against human cancer cell lines and a process for the preparation thereof.
摘要翻译： 本发明提供通式3a-i至6a-i，7a-i至10a-i，12a-i至15a-i，16a-i至19a-i，21a-i至24a-i，25a -i至28a-i，30a-i至33a-i，34a-i至37a-i和39a-i至42a-i，43a-i至46a-i可用作抗人肿瘤细胞系的潜在抗肿瘤剂 其制备方法。
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![Isoxazoline linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and the process for preparation thereof](/abs-image/US/2013/02/12/US08372831B2/abs.jpg.150x150.jpg)
5.发明授权Isoxazoline linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and the process for preparation thereof 有权异恶唑啉连接的吡咯并[2,1-c] [1,4]苯并二氮杂作为潜在的抗癌剂及其制备方法公开(公告)号：US08372831B2
公开(公告)日：2013-02-12
申请号：US12934594
申请日：2008-10-31
IPC分类号： C07D487/04 , A61K31/5517 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds of general formula (5a-d) and (9a-h) useful as potential antitumour agents against human cancer cell lines. The present invention also provides a process for the preparation of pyrrolo [2,1-c][1,4]benzodiazepine hybrids of general formula (5a-d) and (9a-h).
摘要翻译： 本发明提供了可用作抗人肿瘤细胞系的潜在抗肿瘤剂的通式（5a-d）和（9a-h）的化合物。 本发明还提供了制备通式（5a-d）和（9a-h）的吡咯并[2,1-c] [1,4]苯并二氮杂杂化物的方法。
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![Isoxazoline linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and the process for preparation thereof](/abs-image/US/2011/05/19/US20110118237A1/abs.jpg.150x150.jpg)
6.发明申请Isoxazoline linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and the process for preparation thereof 有权异恶唑啉连接的吡咯并[2,1-c] [1,4]苯并二氮杂作为潜在的抗癌剂及其制备方法公开(公告)号：US20110118237A1
公开(公告)日：2011-05-19
申请号：US12934594
申请日：2008-10-31
IPC分类号： A61K31/551 , C07D487/14 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds of general formula (5a-d) and (9a-h) useful as potential antitumour agents against human cancer cell lines. The present invention also provides a process for the preparation of pyrrolo [2,1-c][1,4]benzodiazepine hybrids of general formula (5a-d) and (9a-h).
摘要翻译： 本发明提供了可用作抗人肿瘤细胞系的潜在抗肿瘤剂的通式（5a-d）和（9a-h）的化合物。 本发明还提供了制备通式（5a-d）和（9a-h）的吡咯并[2,1-c] [1,4]苯并二氮杂杂化物的方法。
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