公开(公告)号：US20060222638A1

公开(公告)日：2006-10-05

申请号：US10559649

申请日：2004-06-04

申请人： Kandiah Jeyaseelan ,  Arunmozhiarasi Armugam ,  Siaw Chai ,  Prabhakaran Ramkishen ,  Ponnampalam Gopalakrishnakone ,  Kwon Huat Tan

发明人： Kandiah Jeyaseelan ,  Arunmozhiarasi Armugam ,  Siaw Chai ,  Prabhakaran Ramkishen ,  Ponnampalam Gopalakrishnakone ,  Kwon Huat Tan

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  A61K38/48 ,  C12N9/64

CPC分类号： C07K14/81 ,  A61K38/00 ,  C07K14/43522

摘要： An isolated peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof having the function of HMGCoA reductase inhibitor, phosphomevalonate inhibitor, reducing the accumulation of cholesterol in the cholesterol biosynthesis pathway and/or reducing the level of serum cholesterol. Also disclosed is a pharmaceutical composition comprising the peptide having sequence SEQ ID NO:2 or a variant, derivative and/or fragment thereof. Also disclosed is a method for treatment or prophylaxis of disorders characterised by the accumulation of cholesterol, its by-products and/or related lipid derived products, comprising administering to a subject in need at least one peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof.

摘要翻译： 包含SEQ ID NO：2的氨基酸序列的分离的肽，或其具有HMGCoA还原酶抑制剂，磷酸梅氨酸盐抑制剂的功能的变体，衍生物和/或片段，减少胆固醇在胆固醇生物合成途径中的积累和/或还原 血清胆固醇水平。 还公开了包含具有序列SEQ ID NO：2的肽或其变体，衍生物和/或片段的药物组合物。 还公开了一种用于治疗或预防特征在于胆固醇及其副产物和/或相关的脂质衍生产物的积累的疾病的方法，其包括向需要的受试者施用至少一种包含SEQ ID NO的氨基酸序列的肽 ：2，或其变体，衍生物和/或片段。