公开(公告)号：US20250154200A1

公开(公告)日：2025-05-15

申请号：US18722010

申请日：2022-03-31

Applicant: Kansas State University Research Foundation

Inventor： Jeffrey COMER ,  Ravindra THAKKAR ,  Masaaki TAMURA

IPC: C07K7/64 ,  A61K38/00 ,  A61P35/00 ,  G01N33/569

Abstract: Cancer immunotherapies comprising synthetic oligopep-tide-based immune checkpoint inhibitors, methods of treating cancers using the same, and kits and compositions for treatment.

公开(公告)号：US20250066420A1

公开(公告)日：2025-02-27

申请号：US18696155

申请日：2022-09-27

Applicant: Kansas State University Research Foundation

Inventor： Jeffrey COMER ,  Ettayapuram Ramaprasad Azhagiya SINGAM ,  Masaaki TAMURA ,  Susumu ISHIGURO

IPC: C07K7/08 ,  A61K9/00 ,  A61K38/00 ,  A61P35/00 ,  C12N15/86

Abstract: An immune checkpoint (PD-L1) inhibitor oligopeptide comprising the sequence GTRLKPLIICVQWPGL (SEQ ID NO:1), nucleic acids encoding the oligopeptide, and vectors and cells for delivery nucleic acids encoding the oligopeptide are disclosed. Methods of treating cancer and enhancing anti-tumor immunity are also disclosed.