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公开(公告)号：US20200000906A1
公开(公告)日：2020-01-02
申请号：US16556902
申请日：2019-08-30
Applicant: Kansas State University Research Foundation
Inventor： Roman R. Ganta , Chuanmin Cheng , Arathy D. S. Nair , Deborah Jaworski , Suhasini Ganta
IPC: A61K39/02
Abstract: Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0379 and Ech_0230, and their homologs of other related rickettsial pathogens.
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公开(公告)号：US10434161B2
公开(公告)日：2019-10-08
申请号：US16106546
申请日：2018-08-21
Applicant: Kansas State University Research Foundation
Inventor： Roman R. Ganta , Chuanmin Cheng , Arathy D. S. Nair , Deborah Jaworski , Suhasini Ganta
Abstract: Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0660, Ech_0379, and Ech_0230, and their homologs of other related rickettsial pathogens.
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公开(公告)号：US10751401B2
公开(公告)日：2020-08-25
申请号：US16556902
申请日：2019-08-30
Applicant: Kansas State University Research Foundation
Inventor： Roman R. Ganta , Chuanmin Cheng , Arathy D. S. Nair , Deborah Jaworski , Suhasini Ganta
Abstract: Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0379 and Ech_0230, and their homologs of other related rickettsial pathogens.
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公开(公告)号：US20180360942A1
公开(公告)日：2018-12-20
申请号：US16106546
申请日：2018-08-21
Applicant: Kansas State University Research Foundation
Inventor： Roman R. Ganta , Chuanmin Cheng , Arathy D. S. Nair , Deborah Jaworski , Suhasini Ganta
CPC classification number: A61K39/0233 , A61K2039/522 , A61K2039/552 , A61K2039/575
Abstract: Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0660, Ech_0379, and Ech_0230, and their homologs of other related rickettsial pathogens.
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