公开(公告)号：US20230167159A1

公开(公告)日：2023-06-01

申请号：US17906825

申请日：2021-03-22

Applicant: Kansas State University Research Foundation

Inventor： Waithaka Mwangi ,  Huldah Sang

IPC: C07K14/165 ,  C12N15/86

CPC classification number: C07K14/165 ,  C12N15/86 ,  C12N2770/20034 ,  A61K2039/53

Abstract: A new species of coronavirus, SARS-CoV-2, is the cause of a worldwide pandemic and has resulted in hundreds of thousands of deaths. The present disclosure provides immunological compositions and methods related to the production and administration of such compositions to reduce the severity of, incidence of and transmissibility of SARS-CoV-2.

公开(公告)号：US20230029979A1

公开(公告)日：2023-02-02

申请号：US17755359

申请日：2020-10-30

Applicant: Kansas State University Research Foundation

Inventor： Waithaka Mwangi ,  Huldah Sang

IPC: C12N15/86

Abstract: A vector comprising a BPI3Vc backbone and at least one antigenic insert sequence from a pathogen other than BPI3V is provided. The vector is configured to provide protection against BPI3V as well as against the pathogen from which the insert sequence was obtained.

公开(公告)号：US20220031831A1

公开(公告)日：2022-02-03

申请号：US17309272

申请日：2019-11-13

Applicant: Kansas State University Research Foundation

Inventor： Waithaka Mwangi ,  Shehnaz Lokhandwala

IPC: A61K39/12 ,  C12N15/86 ,  A61P31/20

Abstract: The present disclosure provides immunogenic compositions or vaccines against African Swine Fever Virus (ASFV), methods of making and using such immunogenic compositions or vaccines, and methods of administering such immunogenic compositions or vaccines. In some forms, a plurality of ASFV antigens are combined together into a live-vectored multivalent immunogenic composition. In some forms, the live-vectored multivalent immunogenic composition is a multicistronic expression cassette.