专利检索 ap:("Kansas State University Research Foundation" OR "The UAB Research Foundation") AND inv:"Man Zhang" 第 1 页

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发明申请
COMPOUNDS WITH COPPER- OR ZINC-ACTIVATED TOXICITY AGAINST MICROBIAL INFECTION 有权

公开(公告)号：US20220024877A1

公开(公告)日：2022-01-27

申请号：US17277631

申请日：2019-09-20

申请人： Kansas State University Research Foundation , The UAB Research Foundation

发明人： Stefan H. Bossmann , Madumali Kalubowilage , Man Zhang , Anjana Delpe-Acharige , Kayla Eschliman , Frank Wolschendorf , Olaf Kutsch , Alex Dalecki , Whitney Narmore

IPC分类号： C07D231/42 , C07D231/22 , A61K45/06 , A61P31/04

摘要： Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using same.