公开(公告)号：US20040220090A1

公开(公告)日：2004-11-04

申请号：US10834419

申请日：2004-04-28

申请人： Kansas University Medical Center

发明人： Billy G. Hudson ,  Parvin Todd ,  Raja Gabriel Khalifah ,  Aaron Ashley Booth

IPC分类号： A61K038/16 ,  C07K014/47

CPC分类号： G01N33/6842 ,  A61K31/00 ,  A61K31/04 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4415 ,  A61K31/506 ,  A61K31/675 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  C07K5/06034 ,  C07K5/06052 ,  C07K5/0812 ,  G01N33/68 ,  G01N2400/02 ,  G01N2500/04

摘要： The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions.

公开(公告)号：US20030203877A1

公开(公告)日：2003-10-30

申请号：US10388008

申请日：2003-03-13

申请人： Kansas University Medical Center

发明人： Raja Khalifah ,  Aaron Ashley Booth

IPC分类号： A61K031/675 ,  A61K031/506 ,  A61K031/444 ,  C07D43/14 ,  C07D41/14

CPC分类号： C07D213/66 ,  C07D213/65 ,  C07D401/14 ,  C07F9/58

摘要： The present invention provides novel compounds, pharmaceutical compositions, methods, and kits for inhibiting the conversion of Amadori compounds to post Amadori advanced glycation endproducts, and for treating and preventing chronic tissue damage and diabetic complication