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1.发明授权公开(公告)号：US09950041B2
公开(公告)日：2018-04-24
申请号：US14791979
申请日：2015-07-06
CPC分类号： A61K38/47 , A61K38/00 , C12N9/2462 , C12Y302/01017 , Y02A50/401 , Y02A50/406 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/465 , Y02A50/475
摘要： The present invention is a genetically engineered version of a lysozyme protein wherein the engineered enzyme exhibits enhanced antimicrodial activity, relative to the wild type enzyme, as a result of a reduced overall electrostatic charge. Such an enzyme is an attractive therapeutic candidate for treating microbial or viral infections, particularly in cases where the infection results in an accumulation of polyanion inhibitors at the site of infection. Respiratory tract infections are one example of an infection where such an enzyme might be a particularly useful drug.
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2.发明申请公开(公告)号：US20170128546A1
公开(公告)日：2017-05-11
申请号：US14791979
申请日：2015-07-06
CPC分类号： A61K38/47 , A61K38/00 , C12N9/2462 , C12Y302/01017 , Y02A50/401 , Y02A50/406 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/465 , Y02A50/475
摘要： The present invention is a genetically engineered version of a lysozyme protein wherein the engineered enzyme exhibits enhanced antimicrodial activity, relative to the wild type enzyme, as a result of a reduced overall electrostatic charge. Such an enzyme is an attractive therapeutic candidate for treating microbial or viral infections, particularly in cases where the infection results in an accumulation of polyanion inhibitors at the site of infection. Respiratory tract infections are one example of an infection where such an enzyme might be a particularly useful drug.
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3.发明授权Therapeutic charge engineered variants of lysozyme and methods for using same to treat infections 有权溶菌酶的治疗电荷工程变体和使用它们治疗感染的方法公开(公告)号：US09074201B2
公开(公告)日：2015-07-07
申请号：US13144553
申请日：2010-01-19
申请人： Karl Griswold , Thomas Carr Scanlon
发明人： Karl Griswold , Thomas Carr Scanlon
CPC分类号： A61K38/47 , A61K38/00 , C12N9/2462 , C12Y302/01017 , Y02A50/401 , Y02A50/406 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/465 , Y02A50/475
摘要： The present invention is a genetically engineered version of a lysozyme protein wherein the engineered enzyme exhibits enhanced antimicrobial activity, relative to the wild type enzyme, as a result of a reduced overall electrostatic charge. Such an enzyme is an attractive therapeutic candidate for treating microbial or viral infections, particularly in cases where the infection results in an accumulation of polyanion inhibitors at the site of infection. Respiratory tract infections are one example of an infection where such an enzyme might be a particularly useful drug.
摘要翻译： 本发明是溶菌酶蛋白的基因工程版本，其中由于整体静电电荷降低，相对于野生型酶，工程化酶表现出增强的抗微生物活性。 这种酶是治疗微生物或病毒感染的有吸引力的治疗候选物，特别是在感染导致聚阴离子抑制剂在感染部位积聚的情况下。 呼吸道感染是这种酶可能是特别有用的药物的感染的一个实例。
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4.发明申请Therapeutic Charge Engineered Variants of Lysozyme and Methods for Using Same to Treat Infections 审中-公开溶菌酶的治疗电荷工程变体和使用它们治疗感染的方法公开(公告)号：US20130058912A1
公开(公告)日：2013-03-07
申请号：US13144553
申请日：2010-01-19
申请人： Karl Griswold , Thomas Carr Scanlon
发明人： Karl Griswold , Thomas Carr Scanlon
CPC分类号： A61K38/47 , A61K38/00 , C12N9/2462 , C12Y302/01017 , Y02A50/401 , Y02A50/406 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/465 , Y02A50/475
摘要： The present invention is a genetically engineered version of a lysozyme protein wherein the engineered enzyme exhibits enhanced antimicrobial activity, relative to the wild type enzyme, as a result of a reduced overall electrostatic charge. Such an enzyme is an attractive therapeutic candidate for treating microbial or viral infections, particularly in cases where the infection results in an accumulation of polyanion inhibitors at the site of infection. Respiratory tract infections are one example of an infection where such an enzyme might be a particularly useful drug.
摘要翻译： 本发明是溶菌酶蛋白的基因工程版本，其中由于整体静电电荷降低，相对于野生型酶，工程化酶表现出增强的抗微生物活性。 这种酶是治疗微生物或病毒感染的有吸引力的治疗候选物，特别是在感染导致聚阴离子抑制剂在感染部位积聚的情况下。 呼吸道感染是这种酶可能是特别有用的药物的感染的一个实例。
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