公开(公告)号：US20060165742A1

公开(公告)日：2006-07-27

申请号：US10492674

申请日：2002-10-17

申请人： Karl Reizlein ,  Bernd Klinksiek ,  Jurgen Hinderer ,  Peter Baur ,  Anne Suty-Heinze ,  Astrid Mauler-Machnik ,  Heike Bunjes ,  Kirsten Westesen ,  Jonas Hinnen ,  Albert Hinnen

发明人： Karl Reizlein ,  Bernd Klinksiek ,  Jurgen Hinderer ,  Peter Baur ,  Anne Suty-Heinze ,  Astrid Mauler-Machnik ,  Heike Bunjes ,  Kirsten Westesen ,  Jonas Hinnen ,  Albert Hinnen

IPC分类号： A01N25/00 ,  A61K9/14

CPC分类号： A61K9/5138 ,  A01N25/14 ,  A01N25/28 ,  A61K9/5026

摘要： Novel pulverulent active substance formulations composed of at least one active substance which is solid at room temperature, at least one dispersant, polyvinyl alcohol and if desired, additives, the individual active substance particles being enveloped by a coat of polyvinyl alcohol, being present in the amorphous state, and having diameter in the nanometer range, a process for producing the novel formulations and their use for the application of the active substance they comprise and also a device for carrying out the production process.

摘要翻译： 由至少一种在室温下为固体的活性物质，至少一种分散剂，聚乙烯醇和如果需要的添加剂组成的新型粉状活性物质制剂，所述单个活性物质颗粒被聚乙烯醇包裹，存在于 无定形状态，直径在纳米范围内，制备新型制剂的方法及其用于包含它们的活性物质的用途以及用于进行生产过程的装置。

公开(公告)号：US09522377B2

公开(公告)日：2016-12-20

申请号：US10566972

申请日：2004-08-04

申请人： Gert Wörle ,  Fredrik Tiberg ,  Markus Johnsson ,  Heike Bunjes ,  Britta Siekmann ,  Justas Barauskas

发明人： Gert Wörle ,  Fredrik Tiberg ,  Markus Johnsson ,  Heike Bunjes ,  Britta Siekmann ,  Justas Barauskas

IPC分类号： B01J13/02 ,  A61K9/50 ,  B01J13/00

CPC分类号： B01J13/02 ,  A61K9/5089 ,  B01J13/00

摘要： The present invention provides a method for forming a dispersion comprising non-lamellar amphiphile particles having improved phase behavior, particle size distribution and/or storage stability, said method comprising forming a dispersion of lamellar and optionally non-lamellar particles comprising at least one structuring agent in a polar solvent, heating said particles to an elevated temperature, followed by cooling, wherein said heating is to a temperature and for a period sufficient to provide, after cooling, a measurable improvement in phase behavior, particle size distribution and/or storage stability.

摘要翻译： 本发明提供了一种用于形成分散体的方法，所述分散体包含具有改善的相行为，粒度分布和/或储存稳定性的非层状两亲颗粒，所述方法包括形成层状和任选的非层状颗粒的分散体，其包含至少一种结构化试剂 在极性溶剂中，将所述颗粒加热到升高的温度，随后冷却，其中所述加热至一个温度和足以在冷却后提供相位行为，粒度分布和/或储存稳定性的可测量的改善的温度 。

公开(公告)号：US20070134336A1

公开(公告)日：2007-06-14

申请号：US10566972

申请日：2004-08-04

申请人： Gert Worle ,  Frederik Tiberg ,  Markus Johnsson ,  Heike Bunjes ,  Britta Siekmann ,  Justas Barauskas

发明人： Gert Worle ,  Frederik Tiberg ,  Markus Johnsson ,  Heike Bunjes ,  Britta Siekmann ,  Justas Barauskas

IPC分类号： A61K9/14

CPC分类号： B01J13/02 ,  A61K9/5089 ,  B01J13/00

摘要： The present invention provides a method for forming a dispersion comprising non-lamellar amphiphile particles having improved phase behaviour, particle size distribution and/or storage stability, said method comprising forming a dispersion of lamellar and optionally non-lamellar particles comprising at least one structuring agent in a polar solvent, heating said particles to an elevated temperature, followed by cooling, wherein said heating is to a temperature and for a period sufficient to provide, after cooling, a measurable improvement in phase behaviour, particle size distribution and/or storage stability.

摘要翻译： 本发明提供了一种用于形成分散体的方法，所述分散体包含具有改善的相行为，粒度分布和/或储存稳定性的非层状两亲颗粒，所述方法包括形成层状和任选的非层状颗粒的分散体，其包含至少一种结构化试剂 在极性溶剂中，将所述颗粒加热到升高的温度，随后冷却，其中所述加热至一个温度和足以在冷却后提供相位行为，粒度分布和/或储存稳定性的可测量的改善的温度 。