公开(公告)号：US4451473A

公开(公告)日：1984-05-29

申请号：US398801

申请日：1982-07-16

申请人： Karoly Nador ,  Gabor Kraiss ,  Katalin Sinko ,  Margit Paroczai ,  Egon Karpati ,  Laszlo Szporny

发明人： Karoly Nador ,  Gabor Kraiss ,  Katalin Sinko ,  Margit Paroczai ,  Egon Karpati ,  Laszlo Szporny

IPC分类号： A61K31/395 ,  A61K31/435 ,  A61K31/48 ,  A61K31/4995 ,  A61P9/06 ,  C07D451/14 ,  C07D471/08 ,  A61K31/44

CPC分类号： C07D471/08 ,  Y10S514/821

摘要： New bicyclic compounds of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each represent a C.sub.1-6 alkyl group, andR.sup.3 is an etherified hydroxy group of the formula --CR.sup.4, wherein R.sup.4 is benzyl group, benzhydryl group or a phenyl group bearing optionally a phenyl or a trihalomethyl substituent or one or more halogen substituent(s), orR.sup.3 is an esterified hydroxy group of the formula --OCO--R.sup.5, which representsa phenyl-(C.sub.1-5 alkyl)-carbonyloxy group,a cinnamoyloxy group having optionally a halogen or one or more C.sub.1-4 alkoxy substituent(s),a benzoyloxy group having optionally a C.sub.1-4 alkyl, phenyl or trihalomethyl substituent or one or more C.sub.1-4 alkoxy substituent(s), one or more halo substituent(s) and/or nitro substituent,a benzyloyloxy group,a xanthene-9-carbonyloxy group,an optionally substituted naphthoyloxy group, oran acyloxy group derived from a five- or six-membered heterocyclic carboxylic acid bearing optionally a halo substituent on the ring,are prepared by etherifying or esterifying a bicyclic compound of the general formula (II), ##STR2## wherein R.sup.1 and R.sup.2 are as defined above. The new compounds according to the invention possess anti-arrhythmic effects and can be applied to advantage in the therapy of cardiac rhythm disorders.

摘要翻译： 通式（I）的新的双环化合物，其中R 1和R 2各自表示C 1-6烷基，R 3是式-CR 4的醚化羟基，其中R 4是苄基，二苯甲基 基团或任选带有苯基或三卤甲基取代基或一个或多个卤素取代基的苯基，或R3是式-OCO-R5的酯化羟基，其代表苯基 - （C 1-5烷基） - 具有任选卤素或一个或多个C 1-4烷氧基取代基的肉桂酰氧基，任选具有C 1-4烷基的苯甲酰氧基，苯基或三卤甲基取代基或一个或多个C 1-4烷氧基取代基， ，一个或多个卤素取代基和/或硝基取代基，苯甲酰氧基，呫吨-9-羰氧基，任选取代的萘氧基或衍生自五元或六元杂环羧酸的酰氧基 任选地，环上的卤素取代基通过醚化制备 或酯化通式（II）的双环化合物，其中R 1和R 2如上所定义。 根据本发明的新化合物具有抗心律失常作用，可用于治疗心律失常的优点。