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公开(公告)号：US20120295310A1
公开(公告)日：2012-11-22
申请号：US13528918
申请日：2012-06-21
申请人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
发明人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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公开(公告)号：US08227579B2
公开(公告)日：2012-07-24
申请号：US12870199
申请日：2010-08-27
申请人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
发明人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
IPC分类号： C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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公开(公告)号：US07790862B2
公开(公告)日：2010-09-07
申请号：US11762738
申请日：2007-06-13
IPC分类号： C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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公开(公告)号：US20110059087A1
公开(公告)日：2011-03-10
申请号：US12870199
申请日：2010-08-27
申请人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
发明人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
IPC分类号： A61K39/395 , C07K16/24 , C12N5/0783 , A61P25/28 , A61P1/00
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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5.发明申请METHODS OF INHIBITING INFLAMMATION WITH ANTAGONISTS TO IL-17A, IL-17F, AND IL-23P19 有权用IL-17A，IL-17F和IL-23P19抑制炎症反应的方法公开(公告)号：US20110159589A1
公开(公告)日：2011-06-30
申请号：US13032501
申请日：2011-02-22
申请人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
发明人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
IPC分类号： C12N5/02
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-17A，IL-17F和IL-23的活性。 拮抗剂包括结合IL-23并结合IL-17A或IL-17F的抗体和抗体片段，例如IL-17A和IL-17F交叉反应的抗体。 还公开了包括结合IL-23的抗体或抗体片段和在一个分子上结合IL-17A或IL-17F的抗体或抗体片段的拮抗剂。 还公开了结合IL-23和IL-17F但不结合IL-17A的抗体和抗体片段。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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6.发明授权公开(公告)号：US07910703B2
公开(公告)日：2011-03-22
申请号：US12111117
申请日：2008-04-28
申请人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
发明人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
IPC分类号： C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-17A，IL-17F和IL-23的活性。 拮抗剂包括结合IL-23并结合IL-17A或IL-17F的抗体和抗体片段，例如IL-17A和IL-17F交叉反应的抗体。 还公开了包括结合IL-23的抗体或抗体片段和在一个分子上结合IL-17A或IL-17F的抗体或抗体片段的拮抗剂。 还公开了结合IL-23和IL-17F但不结合IL-17A的抗体和抗体片段。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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7.发明申请ANTAGONISTS TO IL-17A, IL-17F, AND IL-23P19 AND METHODS OF USE 有权对IL-17A，IL-17F和IL-23P19的拮抗作用及其使用方法公开(公告)号：US20080299129A1
公开(公告)日：2008-12-04
申请号：US12111117
申请日：2008-04-28
申请人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
发明人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-17A，IL-17F和IL-23的活性。 拮抗剂包括结合IL-23并结合IL-17A或IL-17F的抗体和抗体片段，例如IL-17A和IL-17F交叉反应的抗体。 还公开了包括结合IL-23的抗体或抗体片段和在一个分子上结合IL-17A或IL-17F的抗体或抗体片段的拮抗剂。 还公开了结合IL-23和IL-17F但不结合IL-17A的抗体和抗体片段。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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8.发明授权Methods of inhibiting inflammation with antagonists to IL-17A, IL-17F, and IL-23P19 有权用IL-17A，IL-17F和IL-23P19拮抗剂抑制炎症的方法公开(公告)号：US08333968B2
公开(公告)日：2012-12-18
申请号：US13032501
申请日：2011-02-22
申请人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
发明人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-17A，IL-17F和IL-23的活性。 拮抗剂包括结合IL-23并结合IL-17A或IL-17F的抗体和抗体片段，例如IL-17A和IL-17F交叉反应的抗体。 还公开了包括结合IL-23的抗体或抗体片段和在一个分子上结合IL-17A或IL-17F的抗体或抗体片段的拮抗剂。 还公开了结合IL-23和IL-17F但不结合IL-17A的抗体和抗体片段。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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公开(公告)号：US20120294862A1
公开(公告)日：2012-11-22
申请号：US13534019
申请日：2012-06-27
申请人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
发明人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
IPC分类号： C07K16/46 , A61P29/00 , A61P11/06 , A61P25/00 , A61P1/00 , A61P19/02 , A61K39/395 , A61P37/00
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-17A，IL-17F和IL-23的活性。 拮抗剂包括结合IL-23并结合IL-17A或IL-17F的抗体和抗体片段，例如IL-17A和IL-17F交叉反应的抗体。 还公开了包括结合IL-23的抗体或抗体片段和在一个分子上结合IL-17A或IL-17F的抗体或抗体片段的拮抗剂。 还公开了结合IL-23和IL-17F但不结合IL-17A的抗体和抗体片段。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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公开(公告)号：US08496936B2
公开(公告)日：2013-07-30
申请号：US13534019
申请日：2012-06-27
申请人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , Robert Mabry , Stephen R. Jaspers , Monica J. Huber
发明人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , Robert Mabry , Stephen R. Jaspers , Monica J. Huber
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
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