公开(公告)号：US4498509A

公开(公告)日：1985-02-12

申请号：US464464

申请日：1983-02-07

申请人： Katsuhiko Kojima ,  Toyomi Tanaka ,  Shigeo Nakajima

发明人： Katsuhiko Kojima ,  Toyomi Tanaka ,  Shigeo Nakajima

IPC分类号： B65B1/18 ,  B65B39/02 ,  B65B1/04 ,  B65B1/10

CPC分类号： B65B1/18 ,  Y10T137/7882

摘要： In the particular filling method disclosed in the specification a side valve type packaging bag is filled by inserting a filling tube into the bag valve, expanding a rubber tube surrounding the filling tube to form a seal with the valve opening, supplying particulate material to the interior of the bag and rotating the filling tube to distribute the particulate material within the bag, and then wetting an adhesive in the valve before withdrawing the filling tube from the bag. The filling apparatus according to the invention includes a filling tube which is mounted for rotation about its axis on a support plate and has a pouring spout directed at an angle to its axis and a pneumatic piston connected to the filling tube to rotate the tube about its axis and weighing mechanism for detecting filling of the bag.

摘要翻译： 在本说明书中公开的特定的填充方法中，通过将填充管插入袋式阀中来填充侧阀式包装袋，使填充管周围的橡胶管膨胀以形成与阀开口的密封，将颗粒材料供应到内部 并旋转填充管以将颗粒材料分散在袋内，然后在从袋中取出填充管之前润湿阀中的粘合剂。 根据本发明的灌装设备包括一个灌装管，其安装成围绕其轴线在支撑板上旋转并且具有与其轴线成一定角度的倾倒嘴和连接到填充管的气动活塞，以使管围绕其旋转 轴和称重机构，用于检测袋的填充。

公开(公告)号：US5977097A

公开(公告)日：1999-11-02

申请号：US176804

申请日：1998-10-22

申请人： Isao Kawamoto ,  Katsuya Ishikawa ,  Katsuhiko Kojima ,  Yasuo Shimoji ,  Satoshi Ohya ,  Munetsugu Morimoto

发明人： Isao Kawamoto ,  Katsuya Ishikawa ,  Katsuhiko Kojima ,  Yasuo Shimoji ,  Satoshi Ohya ,  Munetsugu Morimoto

IPC分类号： A61K31/403 ,  A61P31/04 ,  C07D477/20 ,  A61K31/40 ,  C07D487/04

CPC分类号： C07D477/20

摘要： A 1-methylcarbapenem compound represented by the following formula: ##STR1## [wherein R.sup.1 represents a hydrogen atom or a lower alkyl group, R.sup.2 represents a hydrogen atom or a lower alkyl group, R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkyl group which has a substituent, a cycloalkyl group or a group of formula --C(.dbd.NH)R.sup.4 (in which R.sup.4 represents a hydrogen atom, a lower alkyl group or an amino group)]; or a pharmacologically acceptable salt or derivative thereof. The 1-methylcarbapenem compounds of the present invention exhibit excellent antibacterial activity and are therefore effective as a preventive or remedy of infections.

摘要翻译： 由下式表示的1-甲基碳青霉烯化合物：其中，R 1表示氢原子或低级烷基，R 2表示氢原子或低级烷基，R 3表示氢原子，低级烷基，低级烷基 具有取代基，环烷基或式-C（= NH）R 4（其中R 4表示氢原子，低级烷基或氨基）的基团]。 或其药理学上可接受的盐或其衍生物。 本发明的1-甲基碳青霉烯化合物表现出优异的抗菌活性，因此作为感染的预防或补救是有效的。

公开(公告)号：US6090802A

公开(公告)日：2000-07-18

申请号：US95925

申请日：1998-06-12

申请人： Isao Kawamoto ,  Yasuo Shimoji ,  Katsuya Ishikawa ,  Katsuhiko Kojima ,  Hiroshi Yasuda ,  Satoshi Ohya ,  Yukio Utsui

发明人： Isao Kawamoto ,  Yasuo Shimoji ,  Katsuya Ishikawa ,  Katsuhiko Kojima ,  Hiroshi Yasuda ,  Satoshi Ohya ,  Yukio Utsui

IPC分类号： C07D477/20 ,  A61K31/409

CPC分类号： C07D477/20

摘要： A 1-methylcarbapenem compound represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.2 represents hydrogen or an ester residue; and A represents a group of the formula (A1) ##STR2## wherein n is 0, 1 or 2, P is 0, 1 or 2, R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl and R.sup.4 is a group (Q2) ##STR3## wherein B is phenylene, phenylene(C.sub.1 -C.sub.3)alkyl, cyclohexylene, cyclohexylene(C.sub.1 -C.sub.3)alkyl or C.sub.1 -C.sub.5 alkylene, R.sup.7 is hydrogen or C.sub.1 -C.sub.4 alkyl, and R.sup.14 is a group --C(.dbd.NH)R.sup.8, wherein R.sup.8 is hydrogen or C.sub.1 -C.sub.4 alkyl or a group --NR.sup.9 R.sup.10, wherein R.sup.9 and R.sup.10 are the same or different and are hydrogen or C.sub.1 -C.sub.4 alkyl; or a pharmacologically acceptable salt thereof.

摘要翻译： 由下式（I）表示的1-甲基碳青霉烯化合物：其中R1表示氢或C1-C4烷基; R2代表氢或酯残基; 并且A表示式（A1）的基团，其中n为0,1或2，P为0,1或2，R3为氢或C1-C4烷基，R4为基团（Q2），其中B为亚苯基，亚苯基 （C1-C3）烷基，亚环己基，亚环己基（C1-C3）烷基或C1-C5亚烷基，R7是氢或C1-C4烷基，R14是基团-C（= NH）R8，其中R8是氢或C1 -C4烷基或-NR9R10基团，其中R9和R10相同或不同，为氢或C1-C4烷基; 或其药理学上可接受的盐。