公开(公告)号：US4954512A

公开(公告)日：1990-09-04

申请号：US275193

申请日：1988-11-23

申请人： Katsunori Oguro ,  Hiroshi Nojima ,  Nobuyuki Hashizume ,  Norio Ohno ,  Taketoshi Naito

发明人： Katsunori Oguro ,  Hiroshi Nojima ,  Nobuyuki Hashizume ,  Norio Ohno ,  Taketoshi Naito

IPC分类号： A61K31/235 ,  A61K31/165 ,  A61K31/215 ,  A61K31/44 ,  A61K31/4406 ,  A61P1/04 ,  A61P43/00 ,  C07D211/62 ,  C07D213/75

CPC分类号： C07D213/75 ,  C07D211/62 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927

摘要： An anti-peptic ulcer composition containing, as an active ingredient, a therapeutically effective amount of a compound having the formula (I): ##STR1## wherein A represents H.sub.2 NCH.sub.2 --, ##STR2## B represents ##STR3## D and E each independently represent H, R,--R'CO.sub.2 R,--R'(OH)CO.sub.2 R, ##STR4## wherein X represents H, CONR.sub.2, CONHR, CONH.sub.2, CO.sub.2 H, CO.sub.2 R, or COR or --R'(CO.sub.2 R)--; R' represents a lower alkylene group and R represents a lower alkyl group; F represents H, ##STR5## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.