NOVEL INTERMEDIATE FOR HALICHONDRIN B ANALOG SYNTHESIS AND NOVEL DESULFONYLATION REACTION USED FOR THE INTERMEDIATE
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    发明申请
    NOVEL INTERMEDIATE FOR HALICHONDRIN B ANALOG SYNTHESIS AND NOVEL DESULFONYLATION REACTION USED FOR THE INTERMEDIATE 审中-公开
    用于中间体的HALICHONDRIN B类似物合成和新型脱乙酰化反应的新型中间体

    公开(公告)号:US20090203771A1

    公开(公告)日:2009-08-13

    申请号:US12271731

    申请日:2008-11-14

    IPC分类号: A61K31/365 C07F15/00

    CPC分类号: C07D493/22

    摘要: The present invention provides a novel method for producing a compound represented by formula (III) shown below, which comprises treating a compound represented by formula (I) shown below with a trivalent chromium compound and at least one kind of metal selected from the group consisting of manganese and zinc in a solvent in the presence of a ligand represented by formula (II) shown below, and the present invention further provides the novel compound represented by formula (I).

    摘要翻译: 本发明提供了一种制备由下式(III)表示的化合物的新方法,其包括用三价铬化合物和至少一种选自下列的金属中的至少一种金属来处理由下面所示的式(I)表示的化合物: 的锰和锌在溶剂中,在由下式(II)表示的配位体存在下,本发明还提供由式(I)表示的新型化合物。