公开(公告)号：US06271397B1

公开(公告)日：2001-08-07

申请号：US09326696

申请日：1999-06-07

申请人： Kazuhiro Oomori ,  Yuji Kobayashi ,  Takamitsu Utsukihara ,  Sumio Soya

发明人： Kazuhiro Oomori ,  Yuji Kobayashi ,  Takamitsu Utsukihara ,  Sumio Soya

IPC分类号： C07F906

CPC分类号： A61K8/676 ,  A61K8/02 ,  A61K2800/52 ,  A61Q19/00

摘要： A high-purity L-ascorbic acid-2-phosphoric acid potassium crystal having excellent stability, and a method for simply producing the high-purity L-ascorbic acid-2-phosphoric acid potassium in a high yield by adding dropwise a solution containing L-ascorbic acid-2-phosphoric potassium to methanol or simultaneously mixing methanol and a solution containing L-ascorbic acid-2-phosphoric acid potassium. By the production method of the present invention, high-purity L-ascorbic acid-2-phosphoric acid potassium crystal having excellent stability can be simply produced in a high yield. The L-ascorbic acid-2-phosphoric acid potassium crystal obtained by the production method of the present invention is used for feedstuff, cosmetic materials, medical products, food additive and the like.

摘要翻译： 具有优异稳定性的高纯度L-抗坏血酸-2-磷酸钾晶体和通过滴加含有L的溶液而简单地生产高纯度L-抗坏血酸-2-磷酸钾的方法 - 抗坏血酸-2-磷酸钾与甲醇或同时混合甲醇和含有L-抗坏血酸-2-磷酸钾的溶液。 通过本发明的制造方法，可以以高收率简单地制造具有优异稳定性的高纯度L-抗坏血酸-2-磷酸钾晶体。 通过本发明的制造方法得到的L-抗坏血酸-2-磷酸钾晶体用于饲料，化妆品，医疗用品，食品添加剂等。

公开(公告)号：US07495107B2

公开(公告)日：2009-02-24

申请号：US11260141

申请日：2005-10-28

申请人： C. Akira Horiuchi ,  Ken-ichi Itoh ,  Noriko Nakazato ,  Hideo Iwai ,  Takamitsu Utsukihara ,  Wen Chai

发明人： C. Akira Horiuchi ,  Ken-ichi Itoh ,  Noriko Nakazato ,  Hideo Iwai ,  Takamitsu Utsukihara ,  Wen Chai

IPC分类号： C07D261/08 ,  C07D261/02 ,  A61K31/42

CPC分类号： C07D261/04

摘要： There is provided with a method for manufacturing an isoxazole derivative at a high yield and without discharging waste products, and a novel isoxazole derivative. An isoxazole derivative expressed by Formula (8) is produced by reacting a 1-alkyne compound expressed by Formula (7) with iron(III) nitrate in the presence of acetone or acetophenone: (where R1 is an alkyl, cycloalkyl, phenyl, or other such group); and (where R2 is a methyl or a phenyl).

摘要翻译： 提供了以高产率制造异恶唑衍生物并且不排出废产物的方法，以及新的异恶唑衍生物。 由式（8）表示的异恶唑衍生物通过在丙酮或苯乙酮存在下使式（7）表示的1-炔烃化合物与硝酸铁（III）反应来制备：（其中R1是烷基，环烷基，苯基或 其他这样的组）; 和（其中R 2是甲基或苯基）。

公开(公告)号：US20060247288A1

公开(公告)日：2006-11-02

申请号：US11260141

申请日：2005-10-28

申请人： C. Horiuchi ,  Ken-ichi Itoh ,  Noriko Nakazato ,  Hideo Iwai ,  Takamitsu Utsukihara ,  Wen Chai

发明人： C. Horiuchi ,  Ken-ichi Itoh ,  Noriko Nakazato ,  Hideo Iwai ,  Takamitsu Utsukihara ,  Wen Chai

IPC分类号： A61K31/42 ,  C07D261/02 ,  C07D261/20

CPC分类号： C07D261/04

摘要： There is provided with a method for manufacturing an isoxazole derivative at a high yield and without discharging waste products, and a novel isoxazole derivative. An isoxazole derivative expressed by Formula (8) is produced by reacting a 1-alkyne compound expressed by Formula (7) with iron(III) nitrate in the presence of acetone or acetophenone: (where R1 is an alkyl, cycloalkyl, phenyl, or other such group); and (where R2 is a methyl or a phenyl).

摘要翻译： 提供了以高产率制造异恶唑衍生物并且不排出废产物的方法，以及新的异恶唑衍生物。 由式（8）表示的异恶唑衍生物通过在丙酮或苯乙酮存在下使式（7）表示的1-炔烃化合物与硝酸铁（III）反应来制备：（其中R 1为 烷基，环烷基，苯基或其它这样的基团）; 和（其中R 2是甲基或苯基）。