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    Percutaneous absorption preparation
    1.
    发明授权
    Percutaneous absorption preparation 失效
    经皮吸收制剂

    公开(公告)号：US5882675A

    公开(公告)日：1999-03-16

    申请号：US812545

    申请日：1997-03-07

    申请人： Kazuhisa Ninomiya ,  Shoichi Tokuda ,  Yasuhiro Fukushima

    发明人： Kazuhisa Ninomiya ,  Shoichi Tokuda ,  Yasuhiro Fukushima

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/14 ,  A61L15/44 ,  A61L15/58 ,  A61F13/02

    CPC分类号： A61K9/7061 ,  A61K9/0014 ,  A61L15/58 ,  A61K47/14

    摘要： The present invention provides a percutaneous absorption preparation which has excellent pressure-sensitive adhesive characteristics and exerts excellent percutaneous absorption property. A crosslinking agent is added to a solution of an acrylic copolymer prepared by copolymerizing a (meth)acrylic acid alkyl ester with a functional monomer, and the acrylic copolymer is partially crosslinked. A composition containing the crosslinked acrylic copolymer is pulverized to prepare a pressure-sensitive adhesive solution comprised of the acrylic copolymer containing crosslinked acrylic copolymer particles. Thereafter, a drug for percutaneous absorption use, a percutaneous penetration enhancer are added to the pressure-sensitive adhesive solution, thereby producing the percutaneous absorption preparation.

    摘要翻译： 本发明提供一种经皮吸收制剂，其具有优异的压敏粘合剂特性并且具有优异的经皮吸收性能。 将交联剂加入通过使（甲基）丙烯酸烷基酯与官能单体共聚制备的丙烯酸共聚物的溶液中，并且丙烯酸共聚物部分交联。 将含有交联的丙烯酸共聚物的组合物粉碎以制备由包含交联的丙烯酸共聚物颗粒的丙烯酸共聚物组成的压敏粘合剂溶液。 此后，将经皮吸收用药物，经皮渗透促进剂加入到压敏粘合剂溶液中，从而制备经皮吸收制剂。

    Percutaneous absorption preparation
    2.
    发明授权
    Percutaneous absorption preparation 失效
    经皮吸收制剂

    公开(公告)号：US5618555A

    公开(公告)日：1997-04-08

    申请号：US430384

    申请日：1995-04-28

    申请人： Shoichi Tokuda ,  Kazuhisa Ninomiya ,  Yasuhiro Fukushima ,  Shigeyuki Watanabe ,  Mitsuru Ochiai ,  Mutsuo Okumura ,  Yuko Hosokawa

    发明人： Shoichi Tokuda ,  Kazuhisa Ninomiya ,  Yasuhiro Fukushima ,  Shigeyuki Watanabe ,  Mitsuru Ochiai ,  Mutsuo Okumura ,  Yuko Hosokawa

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K31/485 ,  A61K47/14 ,  A61P25/04 ,  A61F13/00

    CPC分类号： A61K9/7061 ,  A61K31/485 ,  A61K47/14 ,  A61K9/0014 ,  Y10S514/946

    摘要： A percutaneous absorption preparation which is excellent in the skin penetration of a non-narcotic analgesic buprenorphine and can sustain a high blood level in a stable state over a long period of time is provided. The percutaneous absorption preparation for administrating buprenorphine hydrochloride and/or buprenorphine, which comprises a support having on one surface thereof a plaster layer containing a pressure-sensitive adhesive, buprenorphine hydrochloride and/or buprenorphine, and a penetration enhancer, wherein the penetration enhancer comprises a combination of a monoglyceride of a fatty acid having 6 to 8 carbon atoms and isopropyl myristate, and the plaster layer contains at least 10% by weight of a monoglyceride off fatty acid having 6 to 8 carbon atoms and at least 5% by weight off isopropyl myristate, with the proviso that the content of the whole penetration enhancer ranges from 25 to 50% by weight. The combined use of the fatty acid monoglyceride and isopropyl myristate as a penetration enhancer synergistically elevates skin penetration of buprenorphine hydrochloride and/or buprenorphine.

    摘要翻译： 提供了一种在非麻醉性止痛丁丙诺啡的皮肤渗透性优异并能够长期稳定地维持高血液水平的经皮吸收制剂。 用于施用盐酸丁丙诺非和/或丁丙诺啡的经皮吸收制剂，其包含在其一个表面上具有含有压敏粘合剂，盐酸丁丙诺非和/或丁丙诺啡的膏药的支持物和渗透促进剂，其中所述渗透促进剂包含 具有6至8个碳原子的脂肪酸的单酸甘油酯和肉豆蔻酸异丙酯的组合，所述膏药层含有至少10重量％的具有6至8个碳原子的单酸甘油酯脱脂肪酸和至少5重量％的异丙基 肉豆蔻酸酯，条件是全部渗透促进剂的含量为25至50重量％。 将脂肪酸单甘油酯和肉豆蔻酸异丙酯作为渗透促进剂的组合使用协同地提高了丁丙诺啡盐酸盐和/或丁丙诺啡的皮肤渗透。

    Buprenorphine percutaneous absorption preparation
    3.
    发明授权
    Buprenorphine percutaneous absorption preparation 失效
    丁丙诺啡经皮吸收制剂

    公开(公告)号：US6090405A

    公开(公告)日：2000-07-18

    申请号：US896948

    申请日：1997-07-18

    申请人： Kazuhisa Ninomiya ,  Yasuhiro Fukushima ,  Mutsuo Okumura ,  Yuko Hosokawa

    发明人： Kazuhisa Ninomiya ,  Yasuhiro Fukushima ,  Mutsuo Okumura ,  Yuko Hosokawa

    IPC分类号： A61K9/70 ,  A61K31/485 ,  A61K47/14 ,  A61P25/04 ,  A61F13/02

    CPC分类号： A61K9/7061 ,  A61K31/485

    摘要： Disclosed is a buprenorphine percutaneous absorption preparation comprising a backing having formed on one side thereof a pressure-sensitive adhesive layer containing at least one of buprenorphine and a salt thereof, wherein the pressure-sensitive adhesive layer contains an acrylic copolymer and crosslinked acrylic copolymer particles. The buprenorphine percutaneous absorption preparation has excellent pressure-sensitive adhesive characteristics and exerts excellent percutaneous absorption property.

    摘要翻译： 公开了一种丁丙诺啡经皮吸收制剂，其包含在其一面上形成含有丁丙诺啡及其盐中的至少一种的压敏粘合剂层的背衬，其中，所述压敏粘合剂层含有丙烯酸共聚物和交联的丙烯酸共聚物颗粒。 丁丙诺啡经皮吸收制剂具有优异的压敏粘合剂特性，并且具有优异的经皮吸收性能。

    Micro stepping motor
    6.
    发明授权
    Micro stepping motor 失效
    微步进电机

    公开(公告)号：US4205244A

    公开(公告)日：1980-05-27

    申请号：US760828

    申请日：1977-01-21

    申请人： Yasuhiro Fukushima

    发明人： Yasuhiro Fukushima

    IPC分类号： G04C13/11 ,  H02K37/16 ,  H02K37/00

    CPC分类号： G04C13/11 ,  H02K37/16

    摘要： A micro stepping motor for use in compact watches and the like comprises a magnetic core, a coil winding wound on the magnetic core, and a stator formed as one rigid body and connected to the magnetic core to define therewith a closed magnetic flux path. The stator has a necked portion along its length and a hole extends through the stator at the center portion of the necked portion. A rotor having at least one pair of magnetic poles is rotatably disposed within the stator hole with an air gap therebetween. The rotor rest position is determined by either a protrusion on the stator extending into the air gap forming a region of minimum reluctance or a recess in the stator opening into the air gap forming a region of maximum reluctance for the rotor flux.

    摘要翻译： 用于紧凑型手表等的微型步进电机包括磁芯，缠绕在磁芯上的线圈绕组和形成为一个刚体的定子，并连接到磁芯上以形成闭合磁通路径。 定子具有沿其长度的颈部，并且在颈部的中心部分处的孔延伸穿过定子。 具有至少一对磁极的转子可旋转地设置在定子孔内，其间具有气隙。 转子静止位置由形成最小磁阻区域的气隙中的定子上的突起或定子开口中的空隙中的凹部中的突起确定，形成用于转子磁通的最大磁阻的区域。