公开(公告)号：US06506745B1

公开(公告)日：2003-01-14

申请号：US09869428

申请日：2001-06-28

申请人： Kazuo Aisaka ,  Naoya Imagawa ,  Hisato Miyai ,  Satoshi Ogawa

发明人： Kazuo Aisaka ,  Naoya Imagawa ,  Hisato Miyai ,  Satoshi Ogawa

IPC分类号： A61K3155

CPC分类号： C07D417/06

摘要： The present invention relates to a medical composition for atrial fibrillation treatment, comprising a compound represented by the following formula [I]: Formula [I] [wherein R1 represents a hydrogen atom or lower alkoxy group; R2 represents a hydrogen atom, lower alkoxy group or phenyl group (wherein the phenyl group may be substituted with 1 to 3 substituents selected from a group consisting of a hydroxides group and a lower alkoxy group), (wherein R3 represents an acyl group); X represents —CO— or —CH2—, and n represents an integer of 1 or 2.] The present invention also relates to a method of treating atrial fibrillation using said compound, and to the use of said compound for producing a medicine for atrial fibrillation treatment or salts thereof or prodrugs thereof.

摘要翻译： 本发明涉及一种用于心房颤动治疗的医药组合物，其包含由下式[I]表示的化合物：式[I] [其中R 1表示氢原子或低级烷氧基; R2表示氢原子，低级烷氧基或苯基（其中苯基可被1〜3个选自氢氧基和低级烷氧基的取代基取代），（其中R3表示酰基）。 X表示-CO-或-CH2-，n表示1或2的整数。]本发明还涉及使用所述化合物治疗心房颤动的方法，以及所述化合物在制备用于心房的药物中的用途 原纤维化处理或其盐或其前药。