公开(公告)号：US5389380A

公开(公告)日：1995-02-14

申请号：US120859

申请日：1993-08-31

申请人： Kazuo Noda ,  Masao Kobayashi ,  Takashi Osawa ,  Toru Maejima

发明人： Kazuo Noda ,  Masao Kobayashi ,  Takashi Osawa ,  Toru Maejima

IPC分类号： A61K9/22 ,  A61K9/42 ,  A61K9/50 ,  A61K9/52 ,  A61K47/02 ,  A61K47/44 ,  A61K9/16

CPC分类号： A61K9/5078

摘要： A sustained release pharmaceutical preparation comprising a carrier, an effective ingredient layer containing a medicinal compound and a heat-meltable material as a binder which is formed around said carrier and a coating layer containing a non-heat-meltable dissolution-controlling agent and a heat-meltable material as a binder which is formed around said effective ingredient layer and the process for preparing the same. According to the present invention, the formation of the effective ingredient layer and the formation of the coating layer can be successively carried out in the same apparatus without using any solvents or drying step in short hours to give a sustained release pharmaceutical preparation which can release a medicinal compound at a suitable dissolution rate according to the physical property of the medicinal compound.

摘要翻译： 一种持续释放药物制剂，其包含载体，含有药用化合物的有效成分层和作为粘合剂的热熔性材料，其形成在所述载体周围;以及涂层，其含有不可热熔融的溶解控制剂和热 作为在所述有效成分层周围形成的粘合剂的可熔性材料及其制备方法。 根据本发明，可以在相同的装置中连续进行有效成分层的形成和涂层的形成，而不需要在短时间内使用任何溶剂或干燥步骤，得到缓释药物制剂 根据药用化合物的物理性质，以合适的溶解速率进行药物化合物。