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公开(公告)号：US06858593B2
公开(公告)日：2005-02-22
申请号：US10200364
申请日：2002-07-22
申请人： Keith Biggadike , Olga Chetina , Steven John Coote , Andrew Craig , Victor Jacewicz , Michael J. Millan , John F. Seager , Andrew L. Theophilus
发明人： Keith Biggadike , Olga Chetina , Steven John Coote , Andrew Craig , Victor Jacewicz , Michael J. Millan , John F. Seager , Andrew L. Theophilus
摘要： There is provided a crystalline chemical composition comprising a compound of formula (I) in which the crystal lattice is stabilized by the presence of a guest molecule, characterized in the crystalline composition is of space group P212121 having unit cell dimensions of about 7.6±0.6 Å, 12.7±0.7 Å, and 33±3 Å when determined at 120 K.
摘要翻译： 提供了包含式（I）化合物的结晶化学组合物，其中通过客体分子的存在使晶格稳定，其特征在于晶体组成为具有约7.6±0.6的晶胞尺寸的空间群P212121 ，12.7±0.7和33±3。
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公开(公告)号：US06777400B2
公开(公告)日：2004-08-17
申请号：US10241658
申请日：2002-09-11
申请人： Keith Biggadike , Steven John Coote , Andrew Craig , Victor Jacewicz , Michael J. Millan , John F. Seager , Andrew L. Theophilus
发明人： Keith Biggadike , Steven John Coote , Andrew Craig , Victor Jacewicz , Michael J. Millan , John F. Seager , Andrew L. Theophilus
IPC分类号： A61K3158
CPC分类号： C07J17/00
摘要： There is provided a crystalline chemical composition comprising a compound of formula (I) in which the crystal lattice is stabilised by the presence of a guest molecule, characterised in the crystalline composition is of space group P212121 having unit cell dimensions of about 7.6±0.6 Å, 12.7±0.7 Å, and 33±3 Å when determined at 120K.
摘要翻译： 提供了包含式（I）化合物的结晶化学组合物，其中通过客体分子的存在使晶格稳定，其特征在于晶体组成为具有约7.6±0.6的晶胞尺寸的空间群P212121 ，12.7±0.7和33±3。
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公开(公告)号：US06777399B2
公开(公告)日：2004-08-17
申请号：US10067010
申请日：2002-02-04
申请人： Keith Biggadike , Steven John Coote , Andrew S. Craig , Victor W Jacewicz , Michael J. Millan , Rosalyn K. Nice , Brian M Noga , John F. Seager , Andrew L. Theophilus , David M. Crowe
发明人： Keith Biggadike , Steven John Coote , Andrew S. Craig , Victor W Jacewicz , Michael J. Millan , Rosalyn K. Nice , Brian M Noga , John F. Seager , Andrew L. Theophilus , David M. Crowe
IPC分类号： A61K3158
摘要： There is provided a crystalline chemical composition comprising a compound of formula (I) in which the crystal lattice is stabilized by the presence of a guest molecule, characterized in the crystalline composition is of space group P212121 having unit cell dimensions of about 12.1±0.6 Å, 14.9±0.7 Å, and 16.2±0.8 Å when determined at either 120K or 150K.
摘要翻译： 提供了包含式（I）化合物的结晶化学组合物，其中通过客体分子的存在使晶格稳定，其特征在于晶体组成为具有约12.1±0.6的晶胞尺寸的空间群P212121 ，14.9±0.7Å和16.2±0.8Å，当在120K或150K下测定时。
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公开(公告)号：US20050043284A1
公开(公告)日：2005-02-24
申请号：US10503114
申请日：2003-02-04
申请人： Keith Biggadike , Steven Coote , Andrew Craig , David Crowe , Victor Jacewicz , Michael Millan , Rosalyn Nice , Brian Noga , John Seager , Andrew Theophilus
发明人： Keith Biggadike , Steven Coote , Andrew Craig , David Crowe , Victor Jacewicz , Michael Millan , Rosalyn Nice , Brian Noga , John Seager , Andrew Theophilus
IPC分类号： A61K47/02 , A01N57/00 , A61K31/56 , A61K31/57 , A61K31/58 , A61K45/00 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61L9/04 , A61P5/44 , A61P29/00 , A61P37/08 , C07J3/00 , C07J17/00 , C07J31/00 , C07J53/00 , C07J71/00
摘要： There is provided a crystalline complex comprising a compound of formula (I) in which the crystal lattice is stabilised by the presence of a guest molecule, characterised in that the crystalline complex is of space group P212121 having unit cell dimensions of about 12.5±1.0 Å, 15±1.0 Å, and 16.2±1.0 Å when determined at either 120 K or 150 K.
摘要翻译： 提供了包含式（I）化合物的结晶复合物，其中通过客体分子的存在使晶格稳定，其特征在于结晶复合物是具有约12.5±1.0埃的晶胞尺寸的空间群P212121 ，15±1.0和16.2±1.0当在120K或150K下测定时。
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公开(公告)号：US07592329B2
公开(公告)日：2009-09-22
申请号：US10503114
申请日：2003-02-04
申请人： Keith Biggadike , Steven John Coote , Andrew Craig , David Malcolm Crowe , Victor Witold Jacewicz , Michael John Millan , Rosalyn Kay Nice , Brian Noga , John Frederick Seager , Andrew Lewis Theophilus
发明人： Keith Biggadike , Steven John Coote , Andrew Craig , David Malcolm Crowe , Victor Witold Jacewicz , Michael John Millan , Rosalyn Kay Nice , Brian Noga , John Frederick Seager , Andrew Lewis Theophilus
摘要： There is provided a crystalline complex comprising a compound of formula (I) in which the crystal lattice is stabilized by the presence of a guest molecule, characterized in that the crystalline complex is of space group P212121 having unit cell dimensions of about 12.5±1.0 §, 15±1.0 §, and 16.2±1.0 § when determined at either 120K or 150K.
摘要翻译： 提供了一种结晶复合物，其包含式（I）化合物，其中晶格通过客体分子的存在而稳定，其特征在于结晶复合物为具有约12.5±1.0的晶胞尺寸的空间群P212121§ ，15±1.0§和16.2±1.0§当在120K或150K下测定时。
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公开(公告)号：US20120142651A1
公开(公告)日：2012-06-07
申请号：US13370493
申请日：2012-02-10
申请人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
发明人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a method of treatment of allergic rhinitis which comprises administering to a patient a pharmaceutically acceptable amount of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof, wherein the administration is once-per-day and intranasal, and the total daily dose of the compound (I) is 50 to 100 μg.
摘要翻译： 提供了一种治疗过敏性鼻炎的方法，其包括给予患者药学上可接受量的药物制剂，其包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液，其中所述给药是每天一次 和鼻内，化合物（I）的总日剂量为50〜100μg。
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7.发明授权公开(公告)号：US07132532B2
公开(公告)日：2006-11-07
申请号：US10862591
申请日：2004-06-07
IPC分类号： C07J17/00
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： The present invention relates to, for example, a compound of formula (VIII) useful in the manufacture of anti-inflammatory androstane derivatives.
摘要翻译： 本发明涉及例如可用于制造消炎雄甾烷衍生物的式（Ⅷ）化合物。
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公开(公告)号：US07629335B2
公开(公告)日：2009-12-08
申请号：US11428853
申请日：2006-07-06
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.
摘要翻译： 根据本发明的一个方面，提供式（I）的化合物及其溶剂合物。 还提供含有该化合物的组合物，其制备方法及其在治疗中的用途。
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9.发明授权公开(公告)号：US07144845B2
公开(公告)日：2006-12-05
申请号：US10862792
申请日：2004-06-07
IPC分类号： C07J17/00
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： The present invention relates to, for example, compounds of formula (VI) useful in the manufacture of anti-inflammatory androstane derivatives.
摘要翻译： 本发明涉及例如可用于制造抗炎雄甾烷衍生物的式（VI）化合物。
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10.发明授权公开(公告)号：US07125985B2
公开(公告)日：2006-10-24
申请号：US10862555
申请日：2004-06-07
IPC分类号： C07J17/00
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： The present invention relates to, for example, a compound of formula (X) useful in the manufacture of anti-inflammatory androstane derivatives.
摘要翻译： 本发明涉及例如可用于制造抗炎雄甾烷衍生物的式（X）化合物。
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