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公开(公告)号：US06595940B1
公开(公告)日：2003-07-22
申请号：US09430290
申请日：1999-10-29
申请人： Keith R. D'Alessio , William M. Cotter , Upvan Narang , Lawrence H. Mainwaring , Ibraheem T. Badejo , Daniel L. Hedgpeth , Gabriel N. Szabo , Anthony Sherbondy , Joe B. Barefoot
发明人： Keith R. D'Alessio , William M. Cotter , Upvan Narang , Lawrence H. Mainwaring , Ibraheem T. Badejo , Daniel L. Hedgpeth , Gabriel N. Szabo , Anthony Sherbondy , Joe B. Barefoot
IPC分类号： A61M3500
CPC分类号： A61M35/003
摘要： A disposable applicator includes a generally tubular applicator body having a closed proximal end and an open distal end and a frangible vial inside. The proximal end is covered by a drying swab while the distal end is covered by an applicator swab that is in open communication with the interior of the applicator body. Within the applicator body is a frangible vial containing a biomedically useful liquid composition, such as an &agr;-cyanoacrylate adhesive, a medicament, or both. The applicator is useful for applying liquid compositions to target sites such as tissue, particularly sites of topical pathology, such as stomatitis lesions.
摘要翻译： 一次性涂抹器包括一个大致管状的施用器主体，其具有封闭的近端和敞开的远端以及内部易碎的小瓶。 近端由干燥棉签覆盖，而远端由与施用器主体内部开放连通的施用器拭子覆盖。 在施用器主体内是具有生物医学上可用的液体组合物的易碎小瓶，例如α-氰基丙烯酸酯粘合剂，药物或两者。 施用器可用于将液体组合物施用于靶点，例如组织，特别是局部病理部位，例如口腔炎病变。
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2.发明授权Method of applying an adhesive composition over a bioactive polymerization initiator or accelerator 有权将粘合剂组合物涂覆在生物活性聚合引发剂或促进剂上的方法公开(公告)号：US06455064B1
公开(公告)日：2002-09-24
申请号：US09430176
申请日：1999-10-29
IPC分类号： A61K970
CPC分类号： A61L24/0015 , A61K9/0014 , A61K9/7015 , A61K47/32 , A61L24/06 , A61L2300/102 , A61L2300/442 , C08L35/04
摘要： A composition comprising a polymerizable adhesive monomer is applied over a biologically active initiator or accelerator for polymerization of the monomer. The biologically active initiator or accelerator is a medicament that provides a desired medical or therapeutic activity as well as enhancing polymerization of the adhesive.
摘要翻译： 将包含可聚合粘合剂单体的组合物施加到生物活性引发剂或促进剂上以聚合单体。 生物活性引发剂或促进剂是提供所需医学或治疗活性以及增强粘合剂聚合的药物。
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3.发明授权Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto 失效生物相容性聚合物和粘合剂：与其相关的组合物，制备和使用方法公开(公告)号：US07255874B1
公开(公告)日：2007-08-14
申请号：US10024143
申请日：2001-12-21
申请人： John S. Bobo , Julian A. Quintero , Jerry Y. Jonn , Joe B. Barefoot , Jeffrey G. Clark , Upvan Narang , Scott Marc Cannizaro , J. Christopher Marmo
发明人： John S. Bobo , Julian A. Quintero , Jerry Y. Jonn , Joe B. Barefoot , Jeffrey G. Clark , Upvan Narang , Scott Marc Cannizaro , J. Christopher Marmo
IPC分类号： A61K9/127
CPC分类号： A61K9/5026 , A61L24/06 , A61L27/34 , C08L35/04
摘要： Biocompatible polymers and adhesives have a cyanoacrylic core and other substituents such as therapeutic agents, targeting moieties, imaging agents, amino acid residues or other organic moieties. Exemplary uses of inventive compositions include use as sealants and adhesives for medical uses, and as polymeric formulations for biocompatible implants and matrices and drug delivery.
摘要翻译： 生物相容的聚合物和粘合剂具有氰基丙烯酸核心和其它取代基，例如治疗剂，靶向部分，成像剂，氨基酸残基或其它有机部分。 本发明组合物的示例性用途包括用作医疗用途的密封剂和粘合剂，以及用作生物相容性植入物和基质和药物递送的聚合物制剂。
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公开(公告)号：US06340097B1
公开(公告)日：2002-01-22
申请号：US09447045
申请日：1999-11-23
IPC分类号： B65D3700
CPC分类号： A61M35/003 , B05C17/002 , Y10S215/06 , Y10T225/30
摘要： An applicator for dispensing compositions includes a crushable ampoule covered with a barrier material that serves as a protective barrier. The applicator can also include a body made of a flexible material that holds at least one crushable ampoule. The protective barrier protects the user's fingers from puncture by shards created during breakage of the crushable ampoule.
摘要翻译： 用于分配组合物的施加器包括覆盖有用作保护屏障的阻挡材料的可压碎安瓿。 施用器还可以包括由柔性材料制成的主体，其保持至少一个可压碎的安瓿。 保护屏障保护使用者的手指不被可破碎的安瓿破损时产生的碎片穿透。
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公开(公告)号：US06478191B1
公开(公告)日：2002-11-12
申请号：US10012441
申请日：2001-12-12
IPC分类号： B65D3700
CPC分类号： A61M35/003 , B05C17/002 , Y10S215/06 , Y10T225/30
摘要： An applicator for dispensing compositions includes a crushable ampoule covered with a barrier material that serves as a protective barrier. The applicator can also include a body made of a flexible material that holds at least one crushable ampoule. The protective barrier protects the user's fingers from puncture by shards created during breakage of the crushable ampoule.
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