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公开(公告)号:US5536744A
公开(公告)日:1996-07-16
申请号:US363614
申请日:1994-12-23
申请人: Ken Okumura , Ryusuke Tsunoda , Hiroshi Maeda , Takaaki Akaike , Keizo Sato , Kazumi Sasamoto , Yoshiki Katayama
发明人: Ken Okumura , Ryusuke Tsunoda , Hiroshi Maeda , Takaaki Akaike , Keizo Sato , Kazumi Sasamoto , Yoshiki Katayama
IPC分类号: C07D233/52 , A61K31/415 , A61K31/70 , A61K31/7028 , A61P9/08 , A61P9/10 , C07D233/20 , C07D233/22 , C07D233/24 , C07D233/26 , C07D405/12 , C07H15/26
CPC分类号: C07H15/26 , C07D233/22 , C07D233/24 , C07D233/26
摘要: This invention offers the compounds which exhibit a coronary blood vessel dilating action which is long-acting.(Constitution)Novel imidazolinoxyl derivatives represented by a general formula (1). A compound A in which R is COOH is given in an example. ##STR1## (Merit) The compounds of the present invention can be directly administered, after diluting to a suitable concentration with a phosphate buffer or the like, to blood vessel which is required to be relaxed and dilated whereby a significant and long-acting relaxing action is resulted though, in a blood flow, they are quickly inactivated and excreted and no side effect is noted.
摘要翻译: 本发明提供具有长效冠状动脉扩张作用的化合物。 (结构式)由通式(1)表示的新型咪唑啉酰基衍生物。 在一个实例中给出了其中R为COOH的化合物A. (1)(优点)本发明的化合物可以在用磷酸盐缓冲液等稀释至适当浓度之后直接给予需要松弛和扩张的血管,由此显着且长时间 尽管如此,尽管在血液流通中,它们很快被灭活并排泄,并且没有注意到副作用。