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公开(公告)号：US06297014B1
公开(公告)日：2001-10-02
申请号：US09347114
申请日：1999-07-02
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： In a method for detecting a genetic predisposition in a human for non-responsiveness to statin drug treatment for coronary artery disease, nucleic acids comprising nucleotide sequences of the human lipoprotein lipase (LPL) gene are amplified and analyzed. Homozygosity for a variant allele in a non-coding or untranslated region of the 3′ end of LPL, for example, LPL HindIII 2/2 or (TTTA)n 4/4 genotypes, is linked to non-responsiveness to treatment with statin drugs, including lovastatin, pravastatin, simvastatin, atorvastatin, fluvastatin, or cerivastatin. Oligonucleotide primer sequences, primer sets, and genetic testing kits allow the practitioner to practice the method and thus better individualize the treatment and improve the care of patients with coronary artery disease.
摘要翻译： 在用于检测对于冠状动脉疾病的他汀类药物治疗的非反应性的人的遗传易感性的方法中，扩增并分析了包含人脂蛋白脂肪酶（LPL）基因的核苷酸序列的核酸。 在LPL 3'末端的非编码区或非翻译区，例如LPL HindIII 2/2或（TTTA）n 4/4基因型中的变体等位基因的纯合性与对他汀类药物治疗的无反应性有关 ，包括洛伐他汀，普伐他汀，辛伐他汀，阿托伐他汀，氟伐他汀或西立伐他汀。 寡核苷酸引物序列，引物组和遗传测试试剂盒使得从业者能够实施该方法，从而更好地个体化治疗并改善冠状动脉疾病患者的护理。
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公开(公告)号：US20100130600A1
公开(公告)日：2010-05-27
申请号：US12594143
申请日：2008-03-28
申请人： Mark O. Goodarzi , Kent D. Taylor , Maren T. Scheuner , Xiuqing Guo , Prediman K. Shah , Jerome I. Rotter
发明人： Mark O. Goodarzi , Kent D. Taylor , Maren T. Scheuner , Xiuqing Guo , Prediman K. Shah , Jerome I. Rotter
IPC分类号： C12Q1/68 , A61K31/366
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides methods of treating and prognosing atherosclerosis and lipid response to statin treatment by determining the presence or absence of haplotypes at the lipoprotein lipase locus. In one embodiment, the invention is practiced by evaluating the prognosis of vascular grafts in an individual undergoing statin treatment by determining the presence or absence of haplotypes at the lipoprotein locus.
摘要翻译： 本发明提供了通过测定脂蛋白脂肪酶基因座上单倍型的存在或不存在来治疗和预测动脉粥样硬化和对他汀类药物治疗的脂质反应的方法。 在一个实施方案中，本发明通过评估在接受他汀类药物治疗的个体中血管移植物的预后来确定脂蛋白基因座上单体型的存在或不存在来实施。
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3.发明申请PERSONAL ASSESSMENT INCLUDING FAMILIAL RISK ANALYSIS FOR PERSONALIZED DISEASE PREVENTION PLAN 审中-公开个人评估，包括个人风险预防计划的家庭风险分析公开(公告)号：US20140343964A1
公开(公告)日：2014-11-20
申请号：US14260002
申请日：2014-04-23
IPC分类号： G06F19/00
摘要： Family health history information can be used to assess familial risk for common diseases and determine early detection and prevention medical strategies. Assessed familial risk of disease can then be used to determine recommendations for disease prevention and screening that are targeted to familial risk. Other factors can be included to generate personalized disease prevention recommendations. For example, personal health history information, personal health behavior information, or both can be collected and assessed to generate personalized disease prevention recommendations based on the information collected. Recommendations for disease prevention and screening based at least on familial risk can be used to provide a personalized disease prevention plan that encourages a person to make behavior changes that will reduce the risk of disease and utilize preventive health services.
摘要翻译： 家庭健康史资料可用于评估常见疾病的家族性风险，并确定早期检测和预防医疗策略。 评估的家族性疾病风险可用于确定针对家族风险的疾病预防和筛查建议。 可以包括其他因素来产生个性化的疾病预防建议。 例如，可以收集和评估个人健康史信息，个人健康行为信息或两者，以根据所收集的信息产生个性化的疾病预防建议。 至少基于家族风险的疾病预防和筛查建议可用于提供个性化的疾病预防计划，鼓励人们进行行为改变，降低疾病风险并利用预防性卫生服务。
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4.发明授权Personal assessment including familial risk analysis for personalized disease prevention plan 有权个人评估，包括个性化疾病预防计划的家庭风险分析公开(公告)号：US08719045B2
公开(公告)日：2014-05-06
申请号：US11815445
申请日：2006-02-02
摘要： Family health history information can be used to assess familial risk for common diseases and determine early detection and prevention medical strategies. Assessed familial risk of disease can then be used to determine recommendations for disease prevention and screening that are targeted to familial risk. Other factors can be included to generate personalized disease prevention recommendations. For example, personal health history information, personal health behavior information, or both can be collected and assessed to generate personalized disease prevention recommendations based on the information collected. Recommendations for disease prevention and screening based at least on familial risk can be used to provide a personalized disease prevention plan that encourages a person to make behavior changes that will reduce the risk of disease and utilize preventive health services.
摘要翻译： 家庭健康史资料可用于评估常见疾病的家族性风险，并确定早期检测和预防医疗策略。 评估的家族性疾病风险可用于确定针对家族风险的疾病预防和筛查建议。 可以包括其他因素来产生个性化的疾病预防建议。 例如，可以收集和评估个人健康史信息，个人健康行为信息或两者，以根据所收集的信息产生个性化的疾病预防建议。 至少基于家族风险的疾病预防和筛查建议可用于提供个性化的疾病预防计划，鼓励人们进行行为改变，降低疾病风险并利用预防性卫生服务。
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5.发明申请PERSONAL ASSESSMENT INCLUDING FAMILIAL RISK ANALYSIS FOR PERSONALIZED DISEASE PREVENTION PLAN 有权个人评估，包括个人风险预防计划的家庭风险分析公开(公告)号：US20090018863A1
公开(公告)日：2009-01-15
申请号：US11815445
申请日：2006-02-02
IPC分类号： G06Q50/00
摘要： Family health history information can be used to assess familial risk for common diseases and determine early detection and prevention medical strategies. Assessed familial risk of disease can then be used to determine recommendations for disease prevention and screening that are targeted to familial risk. Other factors can be included to generate personalized disease prevention recommendations. For example, personal health history information, personal health behavior information, or both can be collected and assessed to generate personalized disease prevention recommendations based on the information collected. Recommendations for disease prevention and screening based at least on familial risk can be used to provide a personalized disease prevention plan that encourages a person to make behavior changes that will reduce the risk of disease and utilize preventive health services.
摘要翻译： 家庭健康史资料可用于评估常见疾病的家族性风险，并确定早期检测和预防医疗策略。 评估的家族性疾病风险可用于确定针对家族风险的疾病预防和筛查建议。 可以包括其他因素来产生个性化的疾病预防建议。 例如，可以收集和评估个人健康史信息，个人健康行为信息或两者，以根据所收集的信息产生个性化的疾病预防建议。 至少基于家族风险的疾病预防和筛查建议可用于提供个性化的疾病预防计划，鼓励人们进行行为改变，降低疾病风险并利用预防性卫生服务。
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