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    Cross-metathesized polysaccharide derivatives and processes for preparing them
    1.
    发明授权
    Cross-metathesized polysaccharide derivatives and processes for preparing them 有权

    公开(公告)号：US10738134B2

    公开(公告)日：2020-08-11

    申请号：US15025451

    申请日：2014-09-26

    申请人： Kevin J. Edgar ,  Xiangtao Meng ,  John Matson

    发明人： Kevin J. Edgar ,  Xiangtao Meng ,  John Matson

    IPC分类号： C08B3/16 ,  C08B3/00 ,  C08B37/02 ,  C08B37/00 ,  A61K47/38 ,  C08B3/14

    摘要： Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ω-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.

    CROSS-METATHESIZED POLYSACCHARIDE DERIVATIVES AND PROCESSES FOR PREPARING THEM
    2.
    发明申请
    CROSS-METATHESIZED POLYSACCHARIDE DERIVATIVES AND PROCESSES FOR PREPARING THEM 审中-公开
    交联金属多糖衍生物及其制备方法

    公开(公告)号：US20160215068A1

    公开(公告)日：2016-07-28

    申请号：US15025451

    申请日：2014-09-26

    申请人： Kevin J. EDGAR ,  Xiangtao MENG ,  John MATSON

    发明人： Kevin J. Edgar ,  Xiangtao Meng ,  John Matson

    IPC分类号： C08B3/16 ,  C08B3/14 ,  A61K47/38

    CPC分类号： C08B3/16 ,  A61K47/38 ,  C08B3/00 ,  C08B3/14 ,  C08B37/0018 ,  C08B37/0021

    摘要： Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose co-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.

    摘要翻译： 描述了多糖与一种或多种烯烃封端的侧链和交叉复合产物的交叉复分解方法。 在一个示例性实施方案中，描述了通过烯烃交叉复分解合成纤维素共 - 羧酸酯的方法。 反应条件相对温和，烯烃取代的多糖和适当的单体烯烃合成物似乎遵循本文总结的Grubbs规则。 化合物和方法可用于结构性质研究，特别是那些旨在开发用于药物递送的聚合物的那些，例如用于控制释放药物递送系统，控释包衣，药物的增加的生物利用度和维持GI中的药物过饱和度 道。

    POLYSACCHARIDE DERIVATIVES AND CROSS-METATHESIS PROCESSES FOR PREPARING THEM
    4.
    发明申请
    POLYSACCHARIDE DERIVATIVES AND CROSS-METATHESIS PROCESSES FOR PREPARING THEM 审中-公开
    多糖衍生物和制备它们的跨金属过程

    公开(公告)号：US20160376379A1

    公开(公告)日：2016-12-29

    申请号：US15125787

    申请日：2015-03-16

    申请人： Kevin J. Edgar ,  Xiangtao Meng ,  Yifan Dong

    发明人： Kevin J. Edgar ,  Xiangtao Meng ,  Yifan Dong

    IPC分类号： C08B3/16 ,  C08B3/22 ,  C08B3/02

    CPC分类号： C08B3/16 ,  C08B3/02 ,  C08B3/22 ,  C08B11/193 ,  C08B11/20 ,  C08B37/00 ,  C08F290/10 ,  C08L33/02 ,  C08L33/12

    摘要： Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ω-carboxyesters via olefin cross-metathesis with acrylates is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate acrylate partners appear to follow Grubbs rules as summarized herein. Additionally, a method of hydrogenation of the cross-metathesized product is described. The compounds and methods may be useful for waterborne coating applications, adhesives, lubricants, or any product in need of dispersion in an aqueous media.

    摘要翻译： 描述了多糖与一种或多种烯烃封端的侧链和交叉复合产物的交叉复分解方法。 在一个示例性实施方案中，描述了通过烯丙基交错复分解与丙烯酸酯合成纤维素ω-羧酸酯的方法。 反应条件相对温和，烯烃取代的多糖和合适的丙烯酸酯配合物似乎遵循本文总结的Grubbs规则。 另外，描述了交叉复合产物的氢化方法。 化合物和方法可用于水性涂料应用，粘合剂，润滑剂或需要在水性介质中分散的任何产品。