公开(公告)号：US4545936A

公开(公告)日：1985-10-08

申请号：US607268

申请日：1984-05-04

申请人： Kikuo Ishizumi ,  Michihisa Muramatsu ,  Hiromi Sato ,  Norihiko Tanno ,  Noboru Yoshida

发明人： Kikuo Ishizumi ,  Michihisa Muramatsu ,  Hiromi Sato ,  Norihiko Tanno ,  Noboru Yoshida

IPC分类号： A61K31/135 ,  A61K31/22 ,  A61P35/00 ,  C07C225/32 ,  C07C15/24 ,  C07C50/22 ,  C07C50/36

CPC分类号： A61K31/135

摘要： An aminonaphthacene derivative of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R.sup.2 is a hydrogen atom or a hydroxyl group, R.sup.3 is a hydrogen atom or a lower alkanoyl group and R.sup.4 and R.sup.5 are, same or different, each a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or a group of the formula: ##STR2## wherein A is an alkylene group which may have one or more lower alkyl substituent(s) and R.sup.6 and R.sup.7 are, same or different, each a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or a lower aminoalkyl group, and an acid addition salt thereof, which is useful as anti-tumor agent.

摘要翻译： 下式的氨基并萘系衍生物：其中R1是氢原子，羟基或低级烷氧基，R2是氢原子或羟基，R3是氢原子或低级烷酰基， R 4和R 5各自相同或不同，为氢原子，低级烷基，低级羟基烷基或下式基团：其中A为可具有一个或多个低级烷基的亚烷基 取代基和R6和R7各自为氢原子，低级烷基，低级羟烷基或低级氨基烷基，及其酸加成盐，可用作抗肿瘤剂。

公开(公告)号：US4610986A

公开(公告)日：1986-09-09

申请号：US660039

申请日：1984-10-12

申请人： Kikuo Ishizumi ,  Michihisa Muramatsu ,  Norihiko Tanno ,  Hiromi Sato ,  Noboru Yoshida

发明人： Kikuo Ishizumi ,  Michihisa Muramatsu ,  Norihiko Tanno ,  Hiromi Sato ,  Noboru Yoshida

IPC分类号： C07D317/28 ,  A01N43/84 ,  C07C50/16 ,  C07C97/26

CPC分类号： C07D317/28

摘要： A (7S,9S) isomer or its racemic modification of the aminonaphthacene derivative of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R.sup.2 is a hydrogen atom or a hydroxyl group, R.sup.3 and R.sup.4 are each a lower alkoxy group or, when taken together, represent an ethylenedioxy group or an oxo group, A is an ethylene group optionally bearing at least one lower alkyl and Q is a hydroxyl group, a lower alkoxy group or a dimethylamino group, or an acid addition salt thereof, which is useful as an anti-tumor agent.

摘要翻译： A（7S，9S）异构体或其下式的氨基并四苯衍生物的外消旋改性：其中R1是氢原子，羟基或低级烷氧基，R2是氢原子或羟基，R3和 R 4各自为低级烷氧基，或者一起表示亚乙二氧基或氧代基时，A为任选具有至少一个低级烷基并且Q为羟基，低级烷氧基或二甲基氨基的亚乙基， 或其酸加成盐，其可用作抗肿瘤剂。

公开(公告)号：US4540695A

公开(公告)日：1985-09-10

申请号：US407278

申请日：1982-08-11

申请人： Kikuo Ishizumi ,  Naohito Ohashi ,  Michihisa Muramatsu

发明人： Kikuo Ishizumi ,  Naohito Ohashi ,  Michihisa Muramatsu

IPC分类号： C07D235/02 ,  C07D265/12 ,  C07D317/28 ,  C07D413/04 ,  A61K31/13 ,  C07C97/07

CPC分类号： C07D235/02 ,  C07D265/12 ,  C07D317/28 ,  C07D413/04

摘要： Aminonaphthacene derivatives of the formula: ##STR1## wherein A is either one of the following groups: ##STR2## wherein R.sup.1 is a hydrogen atom or a group of the formula: --COR.sup.7, R.sup.2 and R.sup.3 are each a lower alkoxy group or, when taken together, represent an ethylenedioxy group or an oxo group, R.sup.4 and R.sup.5 are both hydrogen atoms or either one of them is a hydrogen atom and the other is a group of the formula: --COR.sup.7, R.sup.6 is a hydrogen atom, a hydroxyl group or a group of the formula: --OCOR.sup.7 and R.sup.7 is a lower alkyl group, a halo(lower)alkyl group, a phenyl group or a halophenyl group, which are useful as anti-microbial and/or anti-tumor agents, or as intermediates in their production.

摘要翻译： 下式的氨基并萘系衍生物：其中A是下列基团之一：其中R 1是氢原子或下式基团-COR 7，R 2和R 3各自是低级烷氧基，或者当 一起代表亚乙二氧基或氧代基，R4和R5都是氢原子，或者它们中的任一个是氢原子，另一个是下式的基团：-COR 7，R 6是氢原子，羟基 或下式的基团：-OCOR 7和R 7是可用作抗微生物和/或抗肿瘤剂的低级烷基，卤代（低级）烷基，苯基或卤代苯基，或作为 中间体在其生产中。