公开(公告)号：US20240287074A1

公开(公告)日：2024-08-29

申请号：US18044190

申请日：2021-09-07

申请人： Kinoxis Therapeutics Pty Ltd

发明人： Hugh ALSOP ,  Tristan REEKIE ,  Ronnie Maxwell LAWRENCE

IPC分类号： C07D487/04 ,  A61K31/5517 ,  A61P25/36

CPC分类号： C07D487/04 ,  A61K31/5517 ,  A61P25/36

摘要： This invention relates to solid forms of 1-methyl-1,4,5, IO-tetrahydropyrazolo[3,4-b][1,5]benzodiazepine freebase possessing desirable pharmacokinetic properties, such as low hygroscopicity and improved thermal stability. These solid forms include a crystalline form of 1-methyl-1,4,5,IO-tetrahydropyrazolo[3,4-b][1,5]benzodiazepine 5 freebase and phosphate and L-tartrate salts of 1-methyl-1,4,5,IO-tetrahydropyrazolo[3,4-b][1,5]benzodiazepine freebase. Pharmaceutical compositions, medicaments and kits comprising these solid forms are also described. Also provided are methods of using these forms to treat various diseases, conditions and disorders.