专利检索 ap:("Kiweon CHA" OR "Korea Institute of Ocean Science & Technology") AND inv:"Kyeon Won LEE" 第 1 页

1.

发明申请
FGF2 POLYPEPTIDE WITH IMPROVED TEMPERATURE STABILITY AND PROTEASE RESISTANCE AND USE THEREOF 有权

公开(公告)号：US20230076299A1

公开(公告)日：2023-03-09

申请号：US17779210

申请日：2020-11-16

申请人： Kiweon CHA , Korea Institute of Ocean Science & Technology

发明人： Jung-Hyun LEE , Hyung-Soon YIM , Young Jun AN , Kyeon Won LEE , Ye Eun JEONG , Kiweon CHA , Won Kyu LEE , Jurang WOO

IPC分类号： C07K14/50 , C12N5/0735

摘要： Provided is a polypeptide having FGF2 activity and improved temperature stability and protease resistance. The polypeptide includes at least one substitution selected from a substitution of aspartic acid (D) with glutamic acid (E) at position 28, a substitution of cysteine (C) with isoleucine (I) or leucine (L) at position 78, or a substitution of cysteine (C) with isoleucine (I) or tryptophan (VV) at position 96 in SEQ ID NO: 1.