公开(公告)号：US07278786B2

公开(公告)日：2007-10-09

申请号：US10555575

申请日：2004-04-26

申请人： Klaus Fiedler ,  Jens Wiegert

发明人： Klaus Fiedler ,  Jens Wiegert

IPC分类号： A61B6/08

CPC分类号： A61B6/4441 ,  A61B6/547

摘要： Method of generating an image of an object by means of an imaging system which has a radiation source that rotates relative to the object about an axis of rotation within a defined rotation angle range, said radiation source projecting radiation onto a radiation detector in order to record projection data, wherein at predefinable relative rotation angle positions of the radiation source a signal projection data is generated, and also apparatus for carrying out this method.

摘要翻译： 通过成像系统生成物体的图像的方法，所述成像系统具有围绕限定的旋转角度范围内的旋转轴线相对于物体旋转的辐射源，所述辐射源将辐射投射到辐射检测器上以便记录 投影数据，其中在辐射源的可预定的相对旋转角度位置产生信号投影数据，以及用于执行该方法的装置。

公开(公告)号：US20070015986A1

公开(公告)日：2007-01-18

申请号：US10555575

申请日：2004-04-26

申请人： Klaus Fiedler ,  Jens Wiegert

发明人： Klaus Fiedler ,  Jens Wiegert

IPC分类号： A61B5/05

CPC分类号： A61B6/4441 ,  A61B6/547

摘要： Method of generating an image of an object by means of an imaging system which has a radiation source that rotates relative to the object about an axis of rotation within a defined rotation angle range, said radiation source projecting radiation onto a radiation detector in order to record projection data, wherein at predefinable relative rotation angle positions of the radiation source a signal which is used to trigger recording of the projection data is generated, and also apparatus for carrying out this method.

摘要翻译： 通过成像系统生成物体的图像的方法，所述成像系统具有围绕限定的旋转角度范围内的旋转轴线相对于物体旋转的辐射源，所述辐射源将辐射投射到辐射检测器上以便记录 投影数据，其中在辐射源的预定的相对旋转角度位置处产生用于触发投影数据的记录的信号，以及用于执行该方法的装置。

公开(公告)号：US07723694B2

公开(公告)日：2010-05-25

申请号：US11467670

申请日：2006-08-28

申请人： Thomas Frach ,  Klaus Fiedler

发明人： Thomas Frach ,  Klaus Fiedler

IPC分类号： G01T1/208

CPC分类号： G01T1/2018 ,  A61B6/037 ,  G01T1/1642 ,  G01T1/248 ,  G01T1/2985 ,  G01T7/005

摘要： A radiation detector includes an array of detector pixels each including an array of detector cells. Each detector cell includes a photodiode biased in a breakdown region and digital circuitry coupled with the photodiode and configured to output a first digital value in a quiescent state and a second digital value responsive to photon detection by the photodiode. Digital triggering circuitry is configured to output a trigger signal indicative of a start of an integration time period responsive to a selected number of one or more of the detector cells tranisitioning from the first digital value to the second digital value. Readout digital circuitry accumulates a count of a number of transitions of detector cells of the array of detector cells from the first digital state to the second digital state over the integration time period.

摘要翻译： 辐射检测器包括检测器像素的阵列，每个检测器像素包括检测器单元的阵列。 每个检测器单元包括偏置在击穿区域中的光电二极管和与光电二极管耦合的数字电路，并且被配置为输出响应于光电二极管的光子检测的静止状态的第一数字值和第二数字值。 数字触发电路被配置为响应于从第一数字值到第二数字值取样的一个或多个检测器单元的选定数量，输出指示积分时间周期开始的触发信号。 读出数字电路在积分时间段内累积检测器单元阵列的检测器单元从第一数字状态到第二数字状态的转移次数的计数。

公开(公告)号：US20080203309A1

公开(公告)日：2008-08-28

申请号：US11467670

申请日：2006-08-28

申请人： Thomas Frach ,  Klaus Fiedler

发明人： Thomas Frach ,  Klaus Fiedler

IPC分类号： G01T1/20 ,  G01T1/24 ,  G01T1/164

CPC分类号： G01T1/2018 ,  A61B6/037 ,  G01T1/1642 ,  G01T1/248 ,  G01T1/2985 ,  G01T7/005

摘要： A radiation detector includes an array of detector pixels each including an array of detector cells. Each detector cell includes a photodiode biased in a breakdown region and digital circuitry coupled with the photodiode and configured to output a first digital value in a quiescent state and a second digital value responsive to photon detection by the photodiode. Digital triggering circuitry is configured to output a trigger signal indicative of a start of an integration time period responsive to a selected number of one or more of the detector cells tranisitioning from the first digital value to the second digital value. Readout digital circuitry accumulates a count of a number of transitions of detector cells of the array of detector cells from the first digital state to the second digital state over the integration time period.

摘要翻译： 辐射检测器包括检测器像素的阵列，每个检测器像素包括检测器单元的阵列。 每个检测器单元包括偏置在击穿区域中的光电二极管和与光电二极管耦合的数字电路，并且被配置为输出响应于光电二极管的光子检测的静止状态的第一数字值和第二数字值。 数字触发电路被配置为响应于从第一数字值到第二数字值取样的一个或多个检测器单元的选定数量，输出指示积分时间周期开始的触发信号。 读出数字电路在积分时间段内累积检测器单元阵列的检测器单元从第一数字状态到第二数字状态的转移次数的计数。

公开(公告)号：US09268033B2

公开(公告)日：2016-02-23

申请号：US12756460

申请日：2010-04-08

申请人： Thomas Frach ,  Klaus Fiedler

发明人： Thomas Frach ,  Klaus Fiedler

IPC分类号： G01T1/208 ,  G01T1/164 ,  G01T1/29 ,  G01T1/24 ,  A61B6/03

CPC分类号： G01T1/2018 ,  A61B6/037 ,  G01T1/1642 ,  G01T1/248 ,  G01T1/2985 ,  G01T7/005

摘要： A radiation detector includes an array of detector pixels each including an array of detector cells. Each detector cell includes a photodiode biased in a breakdown region and digital circuitry coupled with the photodiode and configured to output a first digital value in a quiescent state and a second digital value responsive to photon detection by the photodiode. Digital triggering circuitry is configured to output a trigger signal indicative of a start of an integration time period responsive to a selected number of one or more of the detector cells transitioning from the first digital value to the second digital value. Readout digital circuitry accumulates a count of a number of transitions of detector cells of the array of detector cells from the first digital state to the second digital state over the integration time period.

公开(公告)号：US07626389B2

公开(公告)日：2009-12-01

申请号：US11911831

申请日：2006-03-28

申请人： Klaus Fiedler ,  Jacobus A. J. M. Deckers ,  Thomas Frach

发明人： Klaus Fiedler ,  Jacobus A. J. M. Deckers ,  Thomas Frach

IPC分类号： G01V3/00

CPC分类号： G01R33/481 ,  A61B6/037 ,  A61B6/4417 ,  G01R33/28 ,  G01R33/5673 ,  G06T11/00

摘要： In a combined scanner, a main magnet (20) and magnetic field gradient coils (28) housed in or on a scanner housing (12, 18) acquires spatially encoded magnetic resonances in an imaging region (14). Solid state radiation detectors (50, 50′, 50″) disposed in or on the scanner housing are arranged to detect gamma rays emitted from the imaging region. Time-of-flight positron emission tomography (TOF-PET) processing (52, 54, 58, 60, 62) determines localized lines of response based on (i) locations of substantially simultaneous gamma ray detections output by the radiation detectors and (ii) a time interval between said substantially simultaneous gamma ray detections. TOF-PET reconstruction processing (64) reconstructs the localized lines of response to produce a TOF-PET image. Magnetic resonance imaging (MRI) reconstruction processing (44) reconstructs the acquired magnetic resonances to produce an MRI image.

摘要翻译： 在组合扫描器中，容纳在扫描仪外壳（12,18）中或扫描仪外壳（12,18）上的主磁体（20）和磁场梯度线圈（28）在成像区域（14）中获取空间编码的磁共振。 布置在扫描仪外壳中或扫描仪外壳上的固体辐射检测器（50,50'，50“）布置成用于检测从成像区域发射的伽马射线。 飞行时间正电子发射断层扫描（TOF-PET）处理（52,54,58,60,62）基于（i）由辐射探测器输出的基本上同时的伽马射线检测的位置确定局部的响应线， ）所述基本上同时的伽马射线检测之间的时间间隔。 TOF-PET重建处理（64）重建局部应答线以产生TOF-PET图像。 磁共振成像（MRI）重建处理（44）重建获取的磁共振以产生MRI图像。

公开(公告)号：US20070270693A1

公开(公告)日：2007-11-22

申请号：US11573557

申请日：2005-08-02

申请人： Klaus Fiedler ,  Michael Geagan ,  Gerd Muehllehner ,  Walter Ruetten ,  Andreas Thon

发明人： Klaus Fiedler ,  Michael Geagan ,  Gerd Muehllehner ,  Walter Ruetten ,  Andreas Thon

IPC分类号： A61B6/00

CPC分类号： G01T1/40 ,  A61B6/037 ,  G01T1/208

摘要： A time-of-flight PET nuclear imaging device (A) includes radiation detectors (20, 22, 24), electronic circuits (26, 28, 30, 32) for processing output signals from each of detectors (20), a coincidence detector (34), a time-of-flight calculator (38) and image processing circuitry (40). A calibration system (48) includes an energy source (50, 150) which generates an electrical or optical calibration pulse. The electrical calibration pulse is applied at an input to the electronics at an output of the detector and the optical calibration pulse is applied to a preselected point adjacent a face of each optical sensor (20) of the detectors. A calibration processor (52) measures the time differences between the generation of the calibration pulse and the receipt of a trigger signal from the electronic circuitry by the coincidence detector (34) and adjusts adjustable delay circuits (44, 46) to minimize these time differences.

摘要翻译： 飞行时间PET核成像装置（A）包括用于处理来自每个检测器（20）的输出信号的辐射检测器（20,22,24），电子电路（26,28,30,32），重合检测器 （34），飞行时间计算器（38）和图像处理电路（40）。 校准系统（48）包括产生电或光学校准脉冲的能量源（50,150）。 电校准脉冲在检测器的输出处的电子器件的输入处施加，并且光学校准脉冲被施加到与检测器的每个光学传感器（20）的面相邻的预选点。 校准处理器（52）通过重合检测器（34）测量校准脉冲的产生和来自电子电路的触发信号的接收之间的时间差，并且调节可调延迟电路（44,46）以最小化这些时间差 。

公开(公告)号：US20070194242A1

公开(公告)日：2007-08-23

申请号：US10595741

申请日：2004-11-16

申请人： Klaus Fiedler ,  Torsten Solf ,  Andreas Thon

发明人： Klaus Fiedler ,  Torsten Solf ,  Andreas Thon

IPC分类号： G01T1/20 ,  G01T1/24

CPC分类号： G01T1/2985

摘要： The invention relates to a scintillation layer (20) for a PET-detector. The scintillation layer (20) consists of a plurality of scintillation elements (21) that are joined together in a practically gapless way and that are oriented towards the centre of curvature (24). Depending on the form of the scintillation layer (20), the scintillation elements (21) may have for example the form of a truncated wedge or pyramid.

摘要翻译： 本发明涉及一种用于PET检测器的闪烁层（20）。 闪烁层（20）由多个闪烁元件（21）组成，其以实际无间隙的方式接合在一起并且朝向曲率中心（24）定向。 根据闪烁层（20）的形式，闪烁元件（21）可以具有例如截头楔形或棱锥形的形式。

公开(公告)号：US09335421B2

公开(公告)日：2016-05-10

申请号：US13189886

申请日：2011-07-25

申请人： Thomas Frach ,  Klaus Fiedler

发明人： Thomas Frach ,  Klaus Fiedler

IPC分类号： G01T1/20 ,  G01T1/164 ,  G01T1/29 ,  G01T1/24 ,  A61B6/03

CPC分类号： G01T1/2018 ,  A61B6/037 ,  G01T1/1642 ,  G01T1/248 ,  G01T1/2985 ,  G01T7/005

摘要： A radiation detector includes an array of detector pixels each including an array of detector cells. Each detector cell includes a photodiode biased in a breakdown region and digital circuitry coupled with the photodiode and configured to output a first digital value in a quiescent state and a second digital value responsive to photon detection by the photodiode. Digital triggering circuitry is configured to output a trigger signal indicative of a start of an integration time period responsive to a selected number of one or more of the detector cells transitioning from the first digital value to the second digital value. Readout digital circuitry accumulates a count of a number of transitions of detector cells of the array of detector cells from the first digital state to the second digital state over the integration time period.

公开(公告)号：US08399848B2

公开(公告)日：2013-03-19

申请号：US12836787

申请日：2010-07-15

申请人： Thomas Frach ,  Klaus Fiedler

发明人： Thomas Frach ,  Klaus Fiedler

IPC分类号： G01T1/208

CPC分类号： G01T1/2018 ,  A61B6/037 ,  G01T1/1642 ,  G01T1/248 ,  G01T1/2985 ,  G01T7/005

摘要： A radiation detector includes an array of detector pixels each including an array of detector cells. Each detector cell includes a photodiode biased in a breakdown region and digital circuitry coupled with the photodiode and configured to output a first digital value in a quiescent state and a second digital value responsive to photon detection by the photodiode. Digital triggering circuitry is configured to output a trigger signal indicative of a start of an integration time period responsive to a selected number of one or more of the detector cells transitioning from the first digital value to the second digital value. Readout digital circuitry accumulates a count of a number of transitions of detector cells of the array of detector cells from the first digital state to the second digital state over the integration time period.

摘要翻译： 辐射检测器包括检测器像素的阵列，每个检测器像素包括检测器单元的阵列。 每个检测器单元包括偏置在击穿区域中的光电二极管和与光电二极管耦合的数字电路，并且被配置为输出响应于光电二极管的光子检测的静止状态的第一数字值和第二数字值。 数字触发电路被配置为响应于从第一数字值转换到第二数字值的一个或多个检测器单元的选定数量，输出指示积分时间段开始的触发信号。 读出数字电路在积分时间段内累积检测器单元阵列的检测器单元从第一数字状态到第二数字状态的转移次数的计数。