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公开(公告)号:US07468375B2
公开(公告)日:2008-12-23
申请号:US11115003
申请日:2005-04-25
申请人: Klaus Ruprecht Dress , Qiyue Hu , Ted William Johnson , Michael Bruno Plewe , Steven Paul Tanis , Hai Wang , Anle Yang , Chunfeng Yin , Junhu Zhang
发明人: Klaus Ruprecht Dress , Qiyue Hu , Ted William Johnson , Michael Bruno Plewe , Steven Paul Tanis , Hai Wang , Anle Yang , Chunfeng Yin , Junhu Zhang
IPC分类号: C07D471/02 , A61K31/4745
CPC分类号: C07D471/04
摘要: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐和溶剂合物,它们的合成及其作为人免疫缺陷病毒(“HIV”)整合酶的调节剂或抑制剂的用途。
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公开(公告)号:US07692014B2
公开(公告)日:2010-04-06
申请号:US11114813
申请日:2005-04-25
申请人: Klaus Ruprecht Dress , Qiyue Hu , Ted William Johnson , Michael Bruno Plewe , Steven Paul Tanis , Huichun Zhu , Junhu Zhang
发明人: Klaus Ruprecht Dress , Qiyue Hu , Ted William Johnson , Michael Bruno Plewe , Steven Paul Tanis , Huichun Zhu , Junhu Zhang
IPC分类号: C07D471/04 , A61K31/437
CPC分类号: C07D491/14 , C07D471/14
摘要: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐和溶剂合物,它们的合成及其作为人免疫缺陷病毒(“HIV”)整合酶的调节剂或抑制剂的用途。
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公开(公告)号:US20100137283A1
公开(公告)日:2010-06-03
申请号:US12697513
申请日:2010-02-01
申请人: Klaus Ruprecht Dress , Qiyue Hu , Ted William Johnson , Michael Bruno Plewe , Steven Paul Tanis , Huichun Zhu , Junhu Zhang
发明人: Klaus Ruprecht Dress , Qiyue Hu , Ted William Johnson , Michael Bruno Plewe , Steven Paul Tanis , Huichun Zhu , Junhu Zhang
IPC分类号: A61K31/55 , C12N9/99 , A61K31/551 , A61K31/5377 , A61K31/437 , C07D471/14
CPC分类号: C07D491/14 , C07D471/14
摘要: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐和溶剂合物,它们的合成及其作为人免疫缺陷病毒(“HIV”)整合酶的调节剂或抑制剂的用途。
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公开(公告)号:US20090170846A1
公开(公告)日:2009-07-02
申请号:US12088583
申请日:2006-09-22
申请人: Klaus Ruprecht Dress , Michael Bruno Plewe , Ted William Johnson , Steven Paul Tanis , Khanh Tuan Tran
发明人: Klaus Ruprecht Dress , Michael Bruno Plewe , Ted William Johnson , Steven Paul Tanis , Khanh Tuan Tran
IPC分类号: A61K31/5377 , C07D471/04 , A61K31/437 , C07D413/14 , A61P31/18 , C12N7/06
CPC分类号: C07D471/04
摘要: The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus “HIV” integrase enzyme. Formula (I).
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐和溶剂化物,它们的合成及其作为人免疫缺陷病毒“HIV”整合酶的调节剂或抑制剂的用途。 式(I)。
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公开(公告)号:US07696213B2
公开(公告)日:2010-04-13
申请号:US11854999
申请日:2007-09-13
申请人: Hengmiao Cheng , Dilip Bhumralkar , Klaus Ruprecht Dress , Jacqui Elizabeth Hoffman , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Michael Bruno Plewe , Khanh Tuan Tran
发明人: Hengmiao Cheng , Dilip Bhumralkar , Klaus Ruprecht Dress , Jacqui Elizabeth Hoffman , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Michael Bruno Plewe , Khanh Tuan Tran
IPC分类号: C07D471/04 , C07D487/04 , A61K31/519 , A61P35/00
CPC分类号: C07D471/04
摘要: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kα).
摘要翻译: 本发明涉及新的式(I)的4-甲基吡啶并嘧啶酮化合物及其盐,它们的合成及其作为磷酸肌醇3-激酶α(PI3-Kα)抑制剂的用途。
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公开(公告)号:US08633204B2
公开(公告)日:2014-01-21
申请号:US13587825
申请日:2012-08-16
申请人: Hengmiao Cheng , Dilip Bhumralkar , Klaus Ruprecht Dress , Jacqui Elizabeth Hoffman , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Michael Bruno Plewe , Khanh Tuan Tran
发明人: Hengmiao Cheng , Dilip Bhumralkar , Klaus Ruprecht Dress , Jacqui Elizabeth Hoffman , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Michael Bruno Plewe , Khanh Tuan Tran
IPC分类号: A01N43/90
CPC分类号: C07D471/04
摘要: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kα).
摘要翻译: 本发明涉及式(I)的新颖的4-甲基吡啶并嘧啶酮化合物及其盐,它们的合成及其作为磷酸肌醇3-激酶α(PI3-Kalpha)抑制剂的用途。
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公开(公告)号:US08273755B2
公开(公告)日:2012-09-25
申请号:US12702937
申请日:2010-02-09
申请人: Hengmiao Cheng , Dilip Bhumralkar , Klaus Ruprecht Dress , Jacqui Elizabeth Hoffman , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Michael Bruno Plewe , Khanh Tuan Tran
发明人: Hengmiao Cheng , Dilip Bhumralkar , Klaus Ruprecht Dress , Jacqui Elizabeth Hoffman , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Michael Bruno Plewe , Khanh Tuan Tran
IPC分类号: C07D471/04 , A61K31/519 , A61P35/00
CPC分类号: C07D471/04
摘要: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kα).
摘要翻译: 本发明涉及新的式(I)的4-甲基吡啶并嘧啶酮化合物及其盐,它们的合成及其作为磷酸肌醇3-激酶α(PI3-Kα)抑制剂的用途。
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公开(公告)号:US20100137279A1
公开(公告)日:2010-06-03
申请号:US12702937
申请日:2010-02-09
申请人: Hengmiao Cheng , Dilip Bhumralkar , Klaus Ruprecht Dress , Jacqui Elizabeth Hoffman , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Michael Bruno Plewe , Khanh Tuan Tran
发明人: Hengmiao Cheng , Dilip Bhumralkar , Klaus Ruprecht Dress , Jacqui Elizabeth Hoffman , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Michael Bruno Plewe , Khanh Tuan Tran
IPC分类号: A61K31/519 , C07D471/04 , A61K31/497
CPC分类号: C07D471/04
摘要: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kα).
摘要翻译: 本发明涉及新的式(I)的4-甲基吡啶并嘧啶酮化合物及其盐,它们的合成及其作为磷酸肌醇3-激酶α(PI3-Kα)抑制剂的用途。
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