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    MEDICAMENT FOR PREVENTIVE AND THERAPEUTIC TREATMENT OF PHYSICAL DYSFUNCTION CAUSED BY NERVE DAMAGE
    4.
    发明申请
    MEDICAMENT FOR PREVENTIVE AND THERAPEUTIC TREATMENT OF PHYSICAL DYSFUNCTION CAUSED BY NERVE DAMAGE 失效
    预防和治疗由神经损伤引起的身体功能障碍的药物

    公开(公告)号：US20080182905A1

    公开(公告)日：2008-07-31

    申请号：US11670126

    申请日：2007-02-01

    申请人： Mitsuko Takenaga ,  Koichi Shudo ,  Tetsuro Matsuishi ,  Miwako Ishido

    发明人： Mitsuko Takenaga ,  Koichi Shudo ,  Tetsuro Matsuishi ,  Miwako Ishido

    IPC分类号： A61K31/19

    CPC分类号： A61K31/19

    摘要： A medicament for preventive and/or therapeutic treatment of a physical dysfunction such as motor dysfunction caused by nerve damage resulting from an accident, cerebral crisis and the like, which comprises as an active ingredient a compound or a salt thereof represented by the following general formula (I): wherein R1 to R5 represents hydrogen atom, an alkyl group, or an alkyl-substituted silyl group, X represents —CONH— or —NHCO—, and A represents a carboxylic acid-substituted aromatic group which may be substituted or a tropolonyl group which may be substituted.

    摘要翻译： 一种用于预防和/或治疗身体功能障碍的药物，所述身体功能障碍例如由事故引起的神经损伤引起的运动功能障碍，脑部危象等，其包含作为活性成分的由以下通式表示的化合物或其盐 （I）：其中R 1至R 5表示氢原子，烷基或烷基取代的甲硅烷基，X表示-CONH-或-NHCO-， A表示可以被取代的羧酸取代的芳基或可以被取代的聚丙二醇基。

    Method for treatment of inflammatory bowel disease
    5.
    发明授权
    Method for treatment of inflammatory bowel disease 失效
    炎症性肠病的治疗方法

    公开(公告)号：US08168677B2

    公开(公告)日：2012-05-01

    申请号：US12559268

    申请日：2009-09-14

    申请人： Koichi Shudo ,  Hiroyuki Kagechika ,  Hiroshi Fukasawa ,  Tetsuro Matsuishi ,  Naoko Katsumura ,  Miwako Ishido

    发明人： Koichi Shudo ,  Hiroyuki Kagechika ,  Hiroshi Fukasawa ,  Tetsuro Matsuishi ,  Naoko Katsumura ,  Miwako Ishido

    IPC分类号： A61K31/192 ,  A61K31/554 ,  A61K31/5513 ,  A61K31/695

    CPC分类号： A61K31/192

    摘要： Method for therapeutic treatment of inflammatory bowel disease, including Crohn's disease, comprising administering to a patient in need thereof a therapeutically effective amount of a composition comprising a retinoid as an active ingredient to treat the inflammatory bowel disease, the retinoid being selected from the group consisting of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl]benzoic acid, 4-[(3,5-bis-trimethylsilylphenyl)carboxamido]benzoic acid, 4-[2,3-(2,5-dimethyl-2,5-hexano)dibenzo[b,f][1,4]thiazepin-11-yl]benzoic acid, and 4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid.

    摘要翻译： 包括克罗恩病在内的治疗性治疗炎症性肠病的方法，包括向有需要的患者施用治疗有效量的包含类视黄醇作为活性成分以治疗炎性肠病的组合物，所述类视色素选自 的4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸，4 - [（3,5-双三甲基甲硅烷基苯基）甲酰氨基]苯甲酸 ，4- [2,3-（2,5-二甲基-2,5-己烷）二苯并[b，f] [1,4]硫杂吖庚因-11-基]苯甲酸和4-（5H- ，9,10-四氢-5,7,7,10,10-五甲基苯并[e]萘并[2,3-b] [1,4]二氮杂-13-基）苯甲酸。

    Method for treatment of adhesion of the intestines
    6.
    发明授权
    Method for treatment of adhesion of the intestines 失效
    治疗肠粘连的方法

    公开(公告)号：US08071647B2

    公开(公告)日：2011-12-06

    申请号：US12872171

    申请日：2010-08-31

    申请人： Koichi Shudo ,  Hiroyuki Kagechika ,  Hiroshi Fukasawa ,  Tetsuro Matsuishi ,  Naoko Katsumura ,  Miwako Ishido

    发明人： Koichi Shudo ,  Hiroyuki Kagechika ,  Hiroshi Fukasawa ,  Tetsuro Matsuishi ,  Naoko Katsumura ,  Miwako Ishido

    IPC分类号： A61K31/196

    CPC分类号： A61K31/192

    摘要： Method for suppressing adhesion of the intestines or therapeutic treatment of adhesion of the intestines comprising administering to a patient in need thereof a therapeutically effective amount of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid. There is also provided a medicament for suppressing adhesion of the intestines and/or therapeutic treatment of bowel diseases such as inflammatory bowel diseases, including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.

    摘要翻译： 用于抑制肠粘连的方法或肠道粘连的治疗处理方法，包括向有需要的患者施用治疗有效量的4 - [（5,6,7,8-四氢-5,5,8,8-四氢 - 四甲基-2-萘基）氨基甲酰基]苯甲酸。 还提供了一种用于抑制肠粘连和/或诸如包括克罗恩病在内的肠疾病的肠道疾病的治疗性治疗的药物，其包含类视黄醇作为活性成分，例如4 - [（5， 6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸。